TBXT (T-box transcription factor T)

2018-02-01  

Identity

HGNC
TBXT
LOCATION
6q27
LOCUSID
6862
ALIAS
SAVA,T,TFT

Other Information

Locus ID:

NCBI: 6862
MIM: 601397
HGNC: 11515
Ensembl: ENSG00000164458

Variants:

dbSNP: 6862
ClinVar: 6862
TCGA: ENSG00000164458
COSMIC: TBXT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164458ENST00000296946O15178
ENSG00000164458ENST00000366871O15178
ENSG00000164458ENST00000366876J3KP65
ENSG00000164458ENST00000461348H0YM91

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
218163652011BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.116
198019812009T (brachyury) gene duplication confers major susceptibility to familial chordoma.78
211710782011Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.55
183010552008Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue.46
237880392013The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies.40
188206652008Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis.37
228477332012An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.36
248158642014Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis.35
212201972011Brachyury expression predicts poor prognosis at early stages of colorectal cancer.33
260155442015Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells.33

Citation

Dessen P

TBXT (T-box transcription factor T)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57327/tbxt