TCF7 (transcription factor 7)

2003-02-01  

Identity

HGNC
LOCATION
5q31.1
LOCUSID
ALIAS
TCF-1
FUSION GENES

Other Information

Locus ID:

NCBI: 6932
MIM: 189908
HGNC: 11639
Ensembl: ENSG00000081059

Variants:

dbSNP: 6932
ClinVar: 6932
TCGA: ENSG00000081059
COSMIC: TCF7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081059ENST00000342854P36402
ENSG00000081059ENST00000378560P36402
ENSG00000081059ENST00000395023P36402
ENSG00000081059ENST00000395029B7WNT5
ENSG00000081059ENST00000517741E5RGJ5
ENSG00000081059ENST00000517799H0YAR8
ENSG00000081059ENST00000517851E5RGQ1
ENSG00000081059ENST00000517855H0YBC8
ENSG00000081059ENST00000518887E5RJ51
ENSG00000081059ENST00000518915P36402
ENSG00000081059ENST00000519037E5RHL1
ENSG00000081059ENST00000519447E5RGJ5
ENSG00000081059ENST00000520652H0YBM1
ENSG00000081059ENST00000520699H0YBP2
ENSG00000081059ENST00000520958P36402
ENSG00000081059ENST00000521639E5RG75
ENSG00000081059ENST00000522375E5RG34

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Adherens junctionKEGGko04520
MelanogenesisKEGGko04916
Colorectal cancerKEGGko05210
Endometrial cancerKEGGko05213
Prostate cancerKEGGko05215
Thyroid cancerKEGGko05216
Basal cell carcinomaKEGGko05217
Acute myeloid leukemiaKEGGko05221
Wnt signaling pathwayKEGGhsa04310
Adherens junctionKEGGhsa04520
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Endometrial cancerKEGGhsa05213
Prostate cancerKEGGhsa05215
Thyroid cancerKEGGhsa05216
Basal cell carcinomaKEGGhsa05217
Acute myeloid leukemiaKEGGhsa05221
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Binding of TCF/LEF:CTNNB1 to target gene promotersREACTOMER-HSA-4411364
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124088692002Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.341
258429792015The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling.171
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
164241712006Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo.60
212853522011Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.42
149605822004Wnt activates the Tak1/Nemo-like kinase pathway.41
221117112011Cell-context dependent TCF/LEF expression and function: alternative tales of repression, de-repression and activation potentials.33
213393632011T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitis.31
254369802015MicroRNA-34a regulates WNT/TCF7 signaling and inhibits bone metastasis in Ras-activated prostate cancer.30
227781332012A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs.28

Citation

Dessen P

TCF7 (transcription factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42494/tcf7