TCF7L1 (transcription factor 7 like 1)

2003-11-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
TCF-3,TCF3
FUSION GENES

Other Information

Locus ID:

NCBI: 83439
MIM: 604652
HGNC: 11640
Ensembl: ENSG00000152284

Variants:

dbSNP: 83439
ClinVar: 83439
TCGA: ENSG00000152284
COSMIC: TCF7L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152284ENST00000282111Q9HCS4
ENSG00000152284ENST00000442813C9JPE3

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Adherens junctionKEGGko04520
MelanogenesisKEGGko04916
Colorectal cancerKEGGko05210
Endometrial cancerKEGGko05213
Prostate cancerKEGGko05215
Thyroid cancerKEGGko05216
Basal cell carcinomaKEGGko05217
Acute myeloid leukemiaKEGGko05221
Wnt signaling pathwayKEGGhsa04310
Adherens junctionKEGGhsa04520
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Endometrial cancerKEGGhsa05213
Prostate cancerKEGGhsa05215
Thyroid cancerKEGGhsa05216
Basal cell carcinomaKEGGhsa05217
Acute myeloid leukemiaKEGGhsa05221
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Binding of TCF/LEF:CTNNB1 to target gene promotersREACTOMER-HSA-4411364
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
212853522011Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.42
245962492014Molecular functions of the TLE tetramerization domain in Wnt target gene repression.36
193080212009Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.29
229307472012Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis.29
230901192012Control of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3.23
234927702013TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments.22
256590312015A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.16
267643812016Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.13
230639762012Tcf3 and cell cycle factors contribute to butyrate resistance in colorectal cancer cells.12

Citation

Dessen P

TCF7L1 (transcription factor 7 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42495/tcf7l1