Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6934
MIM: 602228
HGNC: 11641
Ensembl: ENSG00000148737
Variants:
dbSNP: 6934
ClinVar: 6934
TCGA: ENSG00000148737
COSMIC: TCF7L2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10390 | sulfonamides, urea derivatives | Chemical | ClinicalAnnotation | associated | PD | 17519421, 21114608 | |
| PA164712689 | Dipeptidyl peptidase 4 (DPP-4) inhibitors | Chemical | MultilinkAnnotation | associated | 27166975 | ||
| PA165817016 | Kidney Transplantation | Disease | ClinicalAnnotation | associated | PD | 21857094, 23041303 | |
| PA443890 | Diabetes Mellitus, Type 2 | Disease | ClinicalAnnotation, Literature, MultilinkAnnotation | associated | PD | 17519421, 20054294, 24595071 | |
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | ||
| PA447247 | liver transplantation | Disease | ClinicalAnnotation | associated | PD | 21857094, 23041303 | |
| PA449167 | cyclosporine | Chemical | ClinicalAnnotation | associated | PD | 21857094, 23041303 | |
| PA449899 | hydrochlorothiazide | Chemical | ClinicalAnnotation | associated | PD | ||
| PA451234 | repaglinide | Chemical | ClinicalAnnotation | associated | PD | 20054294 | |
| PA451365 | sirolimus | Chemical | ClinicalAnnotation | associated | PD | 21857094, 23041303 | |
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation | associated | PD | 21857094, 23041303 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37798419 | 2024 | Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior. | 3 |
| 38072013 | 2024 | Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes. | 0 |
| 38166877 | 2024 | Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis. | 2 |
| 38372101 | 2024 | MiR-27a-3p exacerbates cell migration and invasion in right-sided/left-sided colorectal cancer by targeting TGFBR2/TCF7L2. | 0 |
| 38492104 | 2024 | Association of Polymorphic Variants of TCF7L2 and PPARG Genes with Metabolic Markers in Patients with Early Disorders of Carbohydrate Metabolism. | 0 |
| 38612849 | 2024 | TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case-Control Study. | 0 |
| 37798419 | 2024 | Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior. | 3 |
| 38072013 | 2024 | Coronary artery disease patients with rs7904519 (TCF7L2) are at a persistent risk of type 2 diabetes. | 0 |
| 38166877 | 2024 | Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis. | 2 |
| 38372101 | 2024 | MiR-27a-3p exacerbates cell migration and invasion in right-sided/left-sided colorectal cancer by targeting TGFBR2/TCF7L2. | 0 |
| 38492104 | 2024 | Association of Polymorphic Variants of TCF7L2 and PPARG Genes with Metabolic Markers in Patients with Early Disorders of Carbohydrate Metabolism. | 0 |
| 38612849 | 2024 | TCF7L2 Polymorphism rs7903146 (C/T) and Gestational Diabetes Influence on Obstetric Outcome: A Romanian Case-Control Study. | 0 |
| 33641658 | 2023 | TCF7L2 (rs7903146) But Not CDKAL1 (rs7754840) Gene Polymorphisms Increase the Risk of New-Onset Diabetes After Kidney Transplant. | 1 |
| 35810738 | 2023 | Association between Transcription Factor 7-Like 2 C/T Polymorphism and Diabetic Retinopathy Risk: A Meta-Analysis. | 3 |
| 36282337 | 2023 | Milder loss of insulin-containing islets in individuals with type 1 diabetes and type 2 diabetes-associated TCF7L2 genetic variants. | 0 |
Citation
Dessen P
TCF7L2 (transcription factor 7 like 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42496/tcf7l2
