TCIM (transcriptional and immune response regulator)

2017-10-01  

Identity

HGNC
LOCATION
8p11.21
LOCUSID
ALIAS
C8orf4,TC-1,TC1

Other Information

Locus ID:

NCBI: 56892
MIM: 607702
HGNC: 1357
Ensembl: ENSG00000176907

Variants:

dbSNP: 56892
ClinVar: 56892
TCGA: ENSG00000176907
COSMIC: TCIM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176907ENST00000315792Q9NR00

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171788572006Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer.63
259857372015C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling.46
150873922004TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer.30
164240012006TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby.25
298428862018Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression.25
167407812006TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer.19
175206782007Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways.15
179058362007The intrinsically disordered TC-1 interacts with Chibby via regions with high helical propensity.12
267444102016Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.12
226586542012Genomic determinants of motor and cognitive outcomes in Parkinson's disease.11

Citation

Dessen P

TCIM (transcriptional and immune response regulator)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57173/tcim