TCP10L (t-complex 10 like)

2014-06-01  

Identity

HGNC
TCP10L
LOCATION
21q22.11
LOCUSID
140290
ALIAS
C21orf77,LINC00846,PRED77,TCP10A-1,TCP10A-2

Other Information

Locus ID:

NCBI: 140290
MIM: 608365
HGNC: 11657
Ensembl: ENSG00000242220

Variants:

dbSNP: 140290
ClinVar: 140290
TCGA: ENSG00000242220
COSMIC: TCP10L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000242220ENST00000300258Q8TDR4
ENSG00000242220ENST00000472557V9GY77
ENSG00000242220ENST00000582575J3KTL9

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
159105422005TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3.4
145867712003Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity.1
154697262004Human liver specific transcriptional factor TCP10L binds to MAD4.1
245658462014TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma.1
266988692016TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction.1

Citation

Dessen P

TCP10L (t-complex 10 like)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53963/tcp10l