TCTN1 (tectonic family member 1)

2015-03-01  

Identity

HGNC
TCTN1
LOCATION
12q24.11
LOCUSID
79600
ALIAS
JBTS13,TECT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79600
MIM: 609863
HGNC: 26113
Ensembl: ENSG00000204852

Variants:

dbSNP: 79600
ClinVar: 79600
TCGA: ENSG00000204852
COSMIC: TCTN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204852ENST00000377654A0A0A0MRU7
ENSG00000204852ENST00000397655Q2MV58
ENSG00000204852ENST00000397656J3KPW2
ENSG00000204852ENST00000397659Q2MV58
ENSG00000204852ENST00000464809E9PIB8
ENSG00000204852ENST00000471804S4R339
ENSG00000204852ENST00000478122E9PIB8
ENSG00000204852ENST00000480648E9PNE4
ENSG00000204852ENST00000481720S4R3G2
ENSG00000204852ENST00000490514E9PR69
ENSG00000204852ENST00000495659E9PIB8
ENSG00000204852ENST00000498072S4R3M8
ENSG00000204852ENST00000546643S4R2Y1
ENSG00000204852ENST00000547461F8VSB8
ENSG00000204852ENST00000549123F8VQ12
ENSG00000204852ENST00000550703B4DIB9
ENSG00000204852ENST00000551590Q2MV58
ENSG00000204852ENST00000552318S4R2Y1
ENSG00000204852ENST00000614115A0A087X1J4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
217253072011A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.274
253040312014Expression and prognostic significance of TCTN1 in human glioblastoma.6
268448472016Tectonic 1 Is a Key Regulator of Cell Proliferation in Pancreatic Cancer.5
263107862015Tectonic‑1 contributes to the growth and migration of prostate cancer cells in vitro.4
281231722017Knockdown of TCTN1 Strongly Decreases Growth of Human Colon Cancer Cells.4
257370232015Lentivirus-Mediated Knockdown of TCTN1 Inhibits Glioma Cell Proliferation.3
286318932017Expanding the allelic disorders linked to TCTN1 to include Varadi syndrome (Orofaciodigital syndrome type VI).1
313029112019[Diagnosis of two cases from one family with Joubert syndrome caused by novel mutations of TCTN1 gene by whole exome sequencing].0

Citation

Dessen P

TCTN1 (tectonic family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55624/tctn1