TDO2 (tryptophan 2,3-dioxygenase)

2017-04-01  

Identity

HGNC
TDO2
LOCATION
4q32.1
LOCUSID
6999
ALIAS
HYPTRP,TDO,TO,TPH2,TRPO
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6999
MIM: 191070
HGNC: 11708
Ensembl: ENSG00000151790

Variants:

dbSNP: 6999
ClinVar: 6999
TCGA: ENSG00000151790
COSMIC: TDO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151790ENST00000506072D6RA50
ENSG00000151790ENST00000507590D6RB68
ENSG00000151790ENST00000536354P48775

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tryptophan metabolismKEGGko00380
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Tryptophan catabolismREACTOMER-HSA-71240
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
153901072005Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons.129
236305702013Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain.35
196372292009Antimicrobial and immunoregulatory properties of human tryptophan 2,3-dioxygenase.33
183704012008A kinetic, spectroscopic, and redox study of human tryptophan 2,3-dioxygenase.22
213613372011Structure and reaction mechanism in the heme dioxygenases.22
126346472003Decreased tryptophan catabolism by placental indoleamine 2,3-dioxygenase in preeclampsia.21
111408382000A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.20
147554472004Association of tryptophan 2,3 dioxygenase gene polymorphism with autism.18
203612202010The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2,3-dioxygenase as revealed by quantum mechanical/molecular mechanical studies.16
218928282011The mechanism of formation of N-formylkynurenine by heme dioxygenases.15

Citation

Dessen P

TDO2 (tryptophan 2,3-dioxygenase)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56848/tdo2