Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55775
MIM: 607198
HGNC: 18884
Ensembl: ENSG00000042088
Variants:
dbSNP: 55775
ClinVar: 55775
TCGA: ENSG00000042088
COSMIC: TDP1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| DNA Repair | REACTOME | R-HSA-73894 |
| DNA Double-Strand Break Repair | REACTOME | R-HSA-5693532 |
| Nonhomologous End-Joining (NHEJ) | REACTOME | R-HSA-5693571 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34974222 | 2022 | TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data. | 3 |
| 35349719 | 2022 | Human TDP1, APE1 and TREX1 repair 3'-DNA-peptide/protein cross-links arising from abasic sites in vitro. | 8 |
| 34974222 | 2022 | TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data. | 3 |
| 35349719 | 2022 | Human TDP1, APE1 and TREX1 repair 3'-DNA-peptide/protein cross-links arising from abasic sites in vitro. | 8 |
| 34356597 | 2021 | New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. | 11 |
| 34356597 | 2021 | New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition. | 11 |
| 32653827 | 2020 | Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases. | 9 |
| 32653827 | 2020 | Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases. | 9 |
| 31199869 | 2019 | Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. | 18 |
| 31226795 | 2019 | Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair. | 2 |
| 31723605 | 2019 | SCAN1-TDP1 trapping on mitochondrial DNA promotes mitochondrial dysfunction and mitophagy. | 16 |
| 31199869 | 2019 | Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. | 18 |
| 31226795 | 2019 | Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair. | 2 |
| 31723605 | 2019 | SCAN1-TDP1 trapping on mitochondrial DNA promotes mitochondrial dysfunction and mitophagy. | 16 |
| 29216365 | 2018 | Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation. | 43 |
Citation
Dessen P
TDP1 (tyrosyl-DNA phosphodiesterase 1)
Atlas Genet Cytogenet Oncol Haematol. 2004-02-01
Online version: http://atlasgeneticsoncology.org/gene/42514/tdp1
