TDP2 (tyrosyl-DNA phosphodiesterase 2)

2010-05-01  

Identity

HGNC
TDP2
LOCATION
6p22.3
LOCUSID
51567
ALIAS
AD022,EAP2,EAPII,TTRAP,dJ30M3.3,hTDP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51567
MIM: 605764
HGNC: 17768
Ensembl: ENSG00000111802

Variants:

dbSNP: 51567
ClinVar: 51567
TCGA: ENSG00000111802
COSMIC: TDP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111802ENST00000341060X6R5A3
ENSG00000111802ENST00000378198O95551
ENSG00000111802ENST00000378198A0A384MDM5

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
197944972009A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.151
248562392014Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).83
210305842011TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.70
252019582014Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses.62
222628802012Genetic variants of FOXP2 and KIAA0319/TTRAP/THEM2 locus are associated with altered brain activation in distinct language-related regions.61
246580032014TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.52
175975872007A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability.45
229082872012An RNA virus hijacks an incognito function of a DNA repair enzyme.42
278144902016Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.40
248081722014Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).37

Citation

Dessen P

TDP2 (tyrosyl-DNA phosphodiesterase 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51498/tdp2