TEAD2 (TEA domain transcription factor 2)

2014-11-01 Affiliation

Identity

HGNC

TEAD2

LOCATION

19q13.33

LOCUSID

8463

ALIAS

ETF,TEAD-2,TEF-4,TEF4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8463
MIM: 601729
HGNC: 11715
Ensembl: ENSG00000074219

Variants:

dbSNP: 8463
ClinVar: 8463
TCGA: ENSG00000074219
COSMIC: TEAD2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000074219	ENST00000311227	Q15562
ENSG00000074219	ENST00000377214	Q15562
ENSG00000074219	ENST00000377214	A0A024QZE2
ENSG00000074219	ENST00000539846	Q15562
ENSG00000074219	ENST00000593945	Q15562
ENSG00000074219	ENST00000596757	M0R290
ENSG00000074219	ENST00000598810	Q15562
ENSG00000074219	ENST00000598823	M0R1A5
ENSG00000074219	ENST00000601519	Q15562
ENSG00000074219	ENST00000601519	A0A024QZE2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Hippo signaling	KEGG	hsa_M00683
Hippo signaling	KEGG	M00683
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expression	REACTOME	R-HSA-2032785
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	REACTOME	R-HSA-400206
PPARA activates gene expression	REACTOME	R-HSA-1989781
Hippo signaling pathway -multiple species	KEGG	ko04392
Hippo signaling pathway -multiple species	KEGG	hsa04392

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20368466	2010	Structural and functional analysis of the YAP-binding domain of human TEAD2.	53
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
25995450	2015	Hippo Component TAZ Functions as a Co-repressor and Negatively Regulates ΔNp63 Transcription through TEA Domain (TEAD) Transcription Factor.	10
31485614	2019	MicroRNA‑608 sensitizes non‑small cell lung cancer cells to cisplatin by targeting TEAD2.	0

Citation

Dessen P

TEAD2 (TEA domain transcription factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74607/tead2