TEN1 (TEN1 subunit of CST complex)

2019-04-01  

Identity

HGNC
TEN1
LOCATION
17q25.1
LOCUSID
100134934
ALIAS
C17orf106
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 100134934
MIM: 613130
HGNC: 37242
Ensembl: ENSG00000257949

Variants:

dbSNP: 100134934
ClinVar: 100134934
TCGA: ENSG00000257949
COSMIC: TEN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000257949ENST00000397640Q86WV5
ENSG00000257949ENST00000586891K7EIL0
ENSG00000257949ENST00000588202K7EL09
ENSG00000257949ENST00000590676K7EJS2

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
198541302009RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway.162
227634452012The human CST complex is a terminator of telomerase activity.130
238513442013CST for the grand finale of telomere replication.28
283347502017CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance.26
274870432016Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress.20
300265502018CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells.12
292934512018Emerging roles of CST in maintaining genome stability and human disease.9
283665362017The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells.6
309768122019Mammalian CST averts replication failure by preventing G-quadruplex accumulation.6
309798242019Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association.1

Citation

Dessen P

TEN1 (TEN1 subunit of CST complex)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57843/ten1