TENT5C (terminal nucleotidyltransferase 5C)

2014-01-01  

Identity

HGNC
LOCATION
1p12
LOCUSID
ALIAS
FAM46C

Other Information

Locus ID:

NCBI: 54855
MIM: 613952
HGNC: 24712
Ensembl: ENSG00000183508

Variants:

dbSNP: 54855
ClinVar: 54855
TCGA: ENSG00000183508
COSMIC: TENT5C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183508ENST00000369448Q5VWP2

References

Pubmed IDYearTitleCitations
219944152011Mapping of chromosome 1p deletions in myeloma identifies FAM46C at 1p12 and CDKN2C at 1p32.3 as being genes in regions associated with adverse survival.45
289318202017The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma.20
264565992016Compendium of FAM46C gene mutations in plasma cell dyscrasias.16
286197092017Loss of FAM46C Promotes Cell Survival in Myeloma.15
283418362017FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.10
277703432017FAM46C Serves as a Predictor of Hepatic Recurrence in Patients with Resectable Gastric Cancer.9
321768232020Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells.1
309106472019FAM46C inhibits lipopolysaccharides-induced myocardial dysfunction via downregulating cellular adhesion molecules and inhibiting apoptosis.0

Citation

Dessen P

TENT5C (terminal nucleotidyltransferase 5C)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53755/tent5c