TESC (tescalcin)

2015-02-01  

Identity

HGNC
LOCATION
12q24.22
LOCUSID
ALIAS
CHP3,TSC
FUSION GENES

Other Information

Locus ID:

NCBI: 54997
MIM: 611585
HGNC: 26065
Ensembl: ENSG00000088992

Variants:

dbSNP: 54997
ClinVar: 54997
TCGA: ENSG00000088992
COSMIC: TESC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088992ENST00000335209Q96BS2
ENSG00000088992ENST00000462502E9PQ58
ENSG00000088992ENST00000470612Q96BS2
ENSG00000088992ENST00000541210Q96BS2
ENSG00000088992ENST00000549210H0YIX4

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183218532008Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform.19
247767392015Multimodal imaging of a tescalcin (TESC)-regulating polymorphism (rs7294919)-specific effects on hippocampal gray matter structure.18
300130432018Tescalcin/c-Src/IGF1Rβ-mediated STAT3 activation enhances cancer stemness and radioresistant properties through ALDH1.12
248111412014The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer.11
200608262010Up- or downregulation of tescalcin in HL-60 cells is associated with their differentiation to either granulocytic or macrophage-like lineage.6
274851122016Tescalcin expression contributes to invasive and metastatic activity in colorectal cancer.6
229842642012N-myristoylation and Ca2+ binding of calcineurin B homologous protein CHP3 are required to enhance Na+/H+ exchanger NHE1 half-life and activity at the plasma membrane.5
246598032014Regulation of Cop9 signalosome activity by the EF-hand Ca2+-binding protein tescalcin.4
285756452017TESC gene-regulating genetic variant (rs7294919) affects hippocampal subfield volumes and parahippocampal cingulum white matter integrity in major depressive disorder.3
259353102015Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.2

Citation

Dessen P

TESC (tescalcin)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55025/tesc