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TESK2 (testis associated actin remodelling kinase 2)

Identity

Alias_namestestis-specific kinase 2
Other alias-
HGNC (Hugo) TESK2
LocusID (NCBI) 10420
Atlas_Id 43527
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 45343883 and ends at 45491168 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SEC23IP (10q26.11) / TESK2 (1p34.1)TESK2 (1p34.1) / CR2 (1q32.2)TESK2 (1p34.1) / GPR37L1 (1q32.1)
TESK2 (1p34.1) / IPP (1p34.1)TESK2 (1p34.1) / MAN1C1 (1p36.11)TESK2 (1p34.1) / PDZK1IP1 (1p33)
TESK2 (1p34.1) / UTS2 (1p36.23)TESK2 1p34.1 / GPR37L1 1q32.1TESK2 1p34.1 / UTS2 1p36.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(1;1)(p34;p32) FGGY/TESK2
t(1;1)(p34;p36) TESK2/UTS2
t(1;1)(p34;q32) TESK2/GPR37L1

External links

Nomenclature
HGNC (Hugo)TESK2   11732
Cards
Entrez_Gene (NCBI)TESK2  10420  testis associated actin remodelling kinase 2
Aliases
GeneCards (Weizmann)TESK2
Ensembl hg19 (Hinxton)ENSG00000070759 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000070759 [Gene_View]  ENSG00000070759 [Sequence]  chr1:45343883-45491168 [Contig_View]  TESK2 [Vega]
ICGC DataPortalENSG00000070759
TCGA cBioPortalTESK2
AceView (NCBI)TESK2
Genatlas (Paris)TESK2
WikiGenes10420
SOURCE (Princeton)TESK2
Genetics Home Reference (NIH)TESK2
Genomic and cartography
GoldenPath hg38 (UCSC)TESK2  -     chr1:45343883-45491168 -  1p34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TESK2  -     1p34.1   [Description]    (hg19-Feb_2009)
GoldenPathTESK2 - 1p34.1 [CytoView hg19]  TESK2 - 1p34.1 [CytoView hg38]
ImmunoBaseENSG00000070759
Mapping of homologs : NCBITESK2 [Mapview hg19]  TESK2 [Mapview hg38]
OMIM604746   
Gene and transcription
Genbank (Entrez)AB057597 AJ132545 AK027573 AK294172 AK299269
RefSeq transcript (Entrez)NM_001320800 NM_007170
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TESK2
Cluster EST : UnigeneHs.591499 [ NCBI ]
CGAP (NCI)Hs.591499
Alternative Splicing GalleryENSG00000070759
Gene ExpressionTESK2 [ NCBI-GEO ]   TESK2 [ EBI - ARRAY_EXPRESS ]   TESK2 [ SEEK ]   TESK2 [ MEM ]
Gene Expression Viewer (FireBrowse)TESK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10420
GTEX Portal (Tissue expression)TESK2
Human Protein AtlasENSG00000070759-TESK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96S53   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96S53  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96S53
Splice isoforms : SwissVarQ96S53
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
PhosPhoSitePlusQ96S53
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Conserved Domain (NCBI)TESK2
DMDM Disease mutations10420
Blocks (Seattle)TESK2
SuperfamilyQ96S53
Human Protein Atlas [tissue]ENSG00000070759-TESK2 [tissue]
Peptide AtlasQ96S53
IPIIPI00102677   IPI00217726   IPI00217728   IPI00910985   IPI01013200   
Protein Interaction databases
DIP (DOE-UCLA)Q96S53
IntAct (EBI)Q96S53
FunCoupENSG00000070759
BioGRIDTESK2
STRING (EMBL)TESK2
ZODIACTESK2
Ontologies - Pathways
QuickGOQ96S53
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  protein phosphorylation  spermatogenesis  nuclear body  peptidyl-tyrosine phosphorylation  actin cytoskeleton organization  actin cytoskeleton organization  metal ion binding  focal adhesion assembly  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  protein phosphorylation  spermatogenesis  nuclear body  peptidyl-tyrosine phosphorylation  actin cytoskeleton organization  actin cytoskeleton organization  metal ion binding  focal adhesion assembly  
NDEx NetworkTESK2
Atlas of Cancer Signalling NetworkTESK2
Wikipedia pathwaysTESK2
Orthology - Evolution
OrthoDB10420
GeneTree (enSembl)ENSG00000070759
Phylogenetic Trees/Animal Genes : TreeFamTESK2
HOGENOMQ96S53
Homologs : HomoloGeneTESK2
Homology/Alignments : Family Browser (UCSC)TESK2
Gene fusions - Rearrangements
Fusion : MitelmanTESK2/GPR37L1 [1p34.1/1q32.1]  
Fusion : MitelmanTESK2/UTS2 [1p34.1/1p36.23]  [t(1;1)(p34;p36)]  
Fusion PortalTESK2 1p34.1 GPR37L1 1q32.1 BRCA
Fusion PortalTESK2 1p34.1 UTS2 1p36.23 BRCA
Fusion : QuiverTESK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTESK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TESK2
dbVarTESK2
ClinVarTESK2
1000_GenomesTESK2 
Exome Variant ServerTESK2
ExAC (Exome Aggregation Consortium)ENSG00000070759
GNOMAD BrowserENSG00000070759
Varsome BrowserTESK2
Genetic variants : HAPMAP10420
Genomic Variants (DGV)TESK2 [DGVbeta]
DECIPHERTESK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTESK2 
Mutations
ICGC Data PortalTESK2 
TCGA Data PortalTESK2 
Broad Tumor PortalTESK2
OASIS PortalTESK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTESK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTESK2
Mutations and Diseases : HGMDTESK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TESK2
DgiDB (Drug Gene Interaction Database)TESK2
DoCM (Curated mutations)TESK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TESK2 (select a term)
intoGenTESK2
Cancer3DTESK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604746   
Orphanet
DisGeNETTESK2
MedgenTESK2
Genetic Testing Registry TESK2
NextProtQ96S53 [Medical]
TSGene10420
GENETestsTESK2
Target ValidationTESK2
Huge Navigator TESK2 [HugePedia]
snp3D : Map Gene to Disease10420
BioCentury BCIQTESK2
ClinGenTESK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10420
Chemical/Pharm GKB GenePA36449
Clinical trialTESK2
Miscellaneous
canSAR (ICR)TESK2 (select the gene name)
DataMed IndexTESK2
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTESK2
EVEXTESK2
GoPubMedTESK2
iHOPTESK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:11:25 CET 2019
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