TEX15 (testis expressed 15, meiosis and synapsis associated)

2009-06-01  

Identity

HGNC
TEX15
LOCATION
8p12
LOCUSID
56154
ALIAS
CT42,SPGF25

Other Information

Locus ID:

NCBI: 56154
MIM: 605795
HGNC: 11738
Ensembl: ENSG00000133863

Variants:

dbSNP: 56154
ClinVar: 56154
TCGA: ENSG00000133863
COSMIC: TEX15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133863ENST00000256246Q9BXT5
ENSG00000133863ENST00000638951A0A1W2PS94
ENSG00000133863ENST00000643185A0A2R8Y358

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.40
261993212015Exome sequencing reveals a nonsense mutation in TEX15 causing spermatogenic failure in a Turkish family.23
225818012012Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population.7
283860632017Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility.5
287306852017TEX15: A DNA repair gene associated with prostate cancer risk in Han Chinese.3
299326162018Expression analysis of genes encoding TEX11, TEX12, TEX14 and TEX15 in testis tissues of men with non-obstructive azoospermia.3
283038062018Case study of a patient with cryptozoospermia associated with a recessive TEX15 nonsense mutation.2

Citation

Dessen P

TEX15 (testis expressed 15, meiosis and synapsis associated)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50954/tex15