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TF (transferrin)

Identity

Alias_symbol (synonym)PRO1557
PRO2086
Other aliasHEL-S-71p
TFQTL1
HGNC (Hugo) TF
LocusID (NCBI) 7018
Atlas_Id 46020
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 133746393 and ends at 133796641 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALB (4q13.3) / TF (3q22.1)LGALS1 (22q13.1) / TF (3q22.1)PICALM (11q14.2) / TF (3q22.1)
TF (3q22.1) / ALB (4q13.3)TF (3q22.1) / CLDN4 (7q11.23)TF (3q22.1) / MATR3 (5q31.2)
TF (3q22.1) / NEAT1 (11q13.1)TF (3q22.1) / TF (3q22.1)TF (3q22.1) / TTL (2q13)
ZFAS1 (20q13.13) / TF (3q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TF   11740
Cards
Entrez_Gene (NCBI)TF  7018  transferrin
AliasesHEL-S-71p; PRO1557; PRO2086; TFQTL1
GeneCards (Weizmann)TF
Ensembl hg19 (Hinxton)ENSG00000091513 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000091513 [Gene_View]  ENSG00000091513 [Sequence]  chr3:133746393-133796641 [Contig_View]  TF [Vega]
ICGC DataPortalENSG00000091513
TCGA cBioPortalTF
AceView (NCBI)TF
Genatlas (Paris)TF
WikiGenes7018
SOURCE (Princeton)TF
Genetics Home Reference (NIH)TF
Genomic and cartography
GoldenPath hg38 (UCSC)TF  -     chr3:133746393-133796641 +  3q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TF  -     3q22.1   [Description]    (hg19-Feb_2009)
GoldenPathTF - 3q22.1 [CytoView hg19]  TF - 3q22.1 [CytoView hg38]
ImmunoBaseENSG00000091513
Mapping of homologs : NCBITF [Mapview hg19]  TF [Mapview hg38]
OMIM190000   209300   
Gene and transcription
Genbank (Entrez)AF118093 AJ252279 AK126941 AK222755 AK293842
RefSeq transcript (Entrez)NM_001063 NM_001354703 NM_001354704
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TF
Alternative Splicing GalleryENSG00000091513
Gene ExpressionTF [ NCBI-GEO ]   TF [ EBI - ARRAY_EXPRESS ]   TF [ SEEK ]   TF [ MEM ]
Gene Expression Viewer (FireBrowse)TF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7018
GTEX Portal (Tissue expression)TF
Human Protein AtlasENSG00000091513-TF [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02787   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02787  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02787
Splice isoforms : SwissVarP02787
PhosPhoSitePlusP02787
Domaine pattern : Prosite (Expaxy)TRANSFERRIN_LIKE_1 (PS00205)    TRANSFERRIN_LIKE_2 (PS00206)    TRANSFERRIN_LIKE_3 (PS00207)    TRANSFERRIN_LIKE_4 (PS51408)   
Domains : Interpro (EBI)Serotransferrin_mammal    Transferrin    Transferrin-like_dom    Transferrin_Fe_BS   
Domain families : Pfam (Sanger)Transferrin (PF00405)   
Domain families : Pfam (NCBI)pfam00405   
Domain families : Smart (EMBL)TR_FER (SM00094)  
Conserved Domain (NCBI)TF
DMDM Disease mutations7018
Blocks (Seattle)TF
PDB (RSDB)1A8E    1A8F    1B3E    1BP5    1BTJ    1D3K    1D4N    1DTG    1FQE    1FQF    1JQF    1N7W    1N7X    1N84    1OQG    1OQH    1RYO    1SUV    2HAU    2HAV    2O7U    2O84    3FGS    3QYT    3S9L    3S9M    3S9N    3SKP    3V83    3V89    3V8X    3VE1    4H0W    4X1B    4X1D    5DYH    5H52    5WTD    5X5P    5Y6K    6CTC    6D03    6D04    6D05    6SOY    6SOZ   
PDB Europe1A8E    1A8F    1B3E    1BP5    1BTJ    1D3K    1D4N    1DTG    1FQE    1FQF    1JQF    1N7W    1N7X    1N84    1OQG    1OQH    1RYO    1SUV    2HAU    2HAV    2O7U    2O84    3FGS    3QYT    3S9L    3S9M    3S9N    3SKP    3V83    3V89    3V8X    3VE1    4H0W    4X1B    4X1D    5DYH    5H52    5WTD    5X5P    5Y6K    6CTC    6D03    6D04    6D05    6SOY    6SOZ   
PDB (PDBSum)1A8E    1A8F    1B3E    1BP5    1BTJ    1D3K    1D4N    1DTG    1FQE    1FQF    1JQF    1N7W    1N7X    1N84    1OQG    1OQH    1RYO    1SUV    2HAU    2HAV    2O7U    2O84    3FGS    3QYT    3S9L    3S9M    3S9N    3SKP    3V83    3V89    3V8X    3VE1    4H0W    4X1B    4X1D    5DYH    5H52    5WTD    5X5P    5Y6K    6CTC    6D03    6D04    6D05    6SOY    6SOZ   
PDB (IMB)1A8E    1A8F    1B3E    1BP5    1BTJ    1D3K    1D4N    1DTG    1FQE    1FQF    1JQF    1N7W    1N7X    1N84    1OQG    1OQH    1RYO    1SUV    2HAU    2HAV    2O7U    2O84    3FGS    3QYT    3S9L    3S9M    3S9N    3SKP    3V83    3V89    3V8X    3VE1    4H0W    4X1B    4X1D    5DYH    5H52    5WTD    5X5P    5Y6K    6CTC    6D03    6D04    6D05    6SOY    6SOZ   
Structural Biology KnowledgeBase1A8E    1A8F    1B3E    1BP5    1BTJ    1D3K    1D4N    1DTG    1FQE    1FQF    1JQF    1N7W    1N7X    1N84    1OQG    1OQH    1RYO    1SUV    2HAU    2HAV    2O7U    2O84    3FGS    3QYT    3S9L    3S9M    3S9N    3SKP    3V83    3V89    3V8X    3VE1    4H0W    4X1B    4X1D    5DYH    5H52    5WTD    5X5P    5Y6K    6CTC    6D03    6D04    6D05    6SOY    6SOZ   
SCOP (Structural Classification of Proteins)1A8E    1A8F    1B3E    1BP5    1BTJ    1D3K    1D4N    1DTG    1FQE    1FQF    1JQF    1N7W    1N7X    1N84    1OQG    1OQH    1RYO    1SUV    2HAU    2HAV    2O7U    2O84    3FGS    3QYT    3S9L    3S9M    3S9N    3SKP    3V83    3V89    3V8X    3VE1    4H0W    4X1B    4X1D    5DYH    5H52    5WTD    5X5P    5Y6K    6CTC    6D03    6D04    6D05    6SOY    6SOZ   
CATH (Classification of proteins structures)1A8E    1A8F    1B3E    1BP5    1BTJ    1D3K    1D4N    1DTG    1FQE    1FQF    1JQF    1N7W    1N7X    1N84    1OQG    1OQH    1RYO    1SUV    2HAU    2HAV    2O7U    2O84    3FGS    3QYT    3S9L    3S9M    3S9N    3SKP    3V83    3V89    3V8X    3VE1    4H0W    4X1B    4X1D    5DYH    5H52    5WTD    5X5P    5Y6K    6CTC    6D03    6D04    6D05    6SOY    6SOZ   
SuperfamilyP02787
Human Protein Atlas [tissue]ENSG00000091513-TF [tissue]
Peptide AtlasP02787
HPRD01811
IPIIPI00022463   IPI00022949   IPI00945626   IPI00877763   IPI00945661   IPI00945828   IPI00790648   IPI00945308   
Protein Interaction databases
DIP (DOE-UCLA)P02787
IntAct (EBI)P02787
FunCoupENSG00000091513
BioGRIDTF
STRING (EMBL)TF
ZODIACTF
Ontologies - Pathways
QuickGOP02787
Ontology : AmiGOretina homeostasis  platelet degranulation  protein binding  extracellular region  extracellular region  extracellular region  extracellular space  early endosome  late endosome  endoplasmic reticulum lumen  clathrin-coated pit  cellular iron ion homeostasis  actin filament organization  activation of JUN kinase activity  ferrous iron binding  ferric iron binding  response to bacterium  basal plasma membrane  cell surface  endosome membrane  apical plasma membrane  endocytic vesicle  osteoclast differentiation  clathrin-coated vesicle membrane  extrinsic component of external side of plasma membrane  cytoplasmic vesicle  regulation of protein stability  vesicle  transferrin transport  regulation of iron ion transport  secretory granule lumen  iron chaperone activity  post-translational protein modification  cellular protein metabolic process  basal part of cell  positive regulation of bone resorption  positive regulation of transcription, DNA-templated  positive regulation of receptor-mediated endocytosis  positive regulation of receptor-mediated endocytosis  perinuclear region of cytoplasm  recycling endosome  iron ion homeostasis  SMAD protein signal transduction  membrane organization  extracellular exosome  ERK1 and ERK2 cascade  cellular response to iron ion  blood microparticle  transferrin receptor binding  transferrin receptor binding  HFE-transferrin receptor complex  positive regulation of cell motility  
Ontology : EGO-EBIretina homeostasis  platelet degranulation  protein binding  extracellular region  extracellular region  extracellular region  extracellular space  early endosome  late endosome  endoplasmic reticulum lumen  clathrin-coated pit  cellular iron ion homeostasis  actin filament organization  activation of JUN kinase activity  ferrous iron binding  ferric iron binding  response to bacterium  basal plasma membrane  cell surface  endosome membrane  apical plasma membrane  endocytic vesicle  osteoclast differentiation  clathrin-coated vesicle membrane  extrinsic component of external side of plasma membrane  cytoplasmic vesicle  regulation of protein stability  vesicle  transferrin transport  regulation of iron ion transport  secretory granule lumen  iron chaperone activity  post-translational protein modification  cellular protein metabolic process  basal part of cell  positive regulation of bone resorption  positive regulation of transcription, DNA-templated  positive regulation of receptor-mediated endocytosis  positive regulation of receptor-mediated endocytosis  perinuclear region of cytoplasm  recycling endosome  iron ion homeostasis  SMAD protein signal transduction  membrane organization  extracellular exosome  ERK1 and ERK2 cascade  cellular response to iron ion  blood microparticle  transferrin receptor binding  transferrin receptor binding  HFE-transferrin receptor complex  positive regulation of cell motility  
Pathways : KEGGHIF-1 signaling pathway    Mineral absorption   
NDEx NetworkTF
Atlas of Cancer Signalling NetworkTF
Wikipedia pathwaysTF
Orthology - Evolution
OrthoDB7018
GeneTree (enSembl)ENSG00000091513
Phylogenetic Trees/Animal Genes : TreeFamTF
HOGENOMP02787
Homologs : HomoloGeneTF
Homology/Alignments : Family Browser (UCSC)TF
Gene fusions - Rearrangements
Fusion : QuiverTF
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TF
dbVarTF
ClinVarTF
1000_GenomesTF 
Exome Variant ServerTF
ExAC (Exome Aggregation Consortium)ENSG00000091513
GNOMAD BrowserENSG00000091513
Varsome BrowserTF
Genetic variants : HAPMAP7018
Genomic Variants (DGV)TF [DGVbeta]
DECIPHERTF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTF 
Mutations
ICGC Data PortalTF 
TCGA Data PortalTF 
Broad Tumor PortalTF
OASIS PortalTF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTF  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTF
Mutations and Diseases : HGMDTF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TF
DgiDB (Drug Gene Interaction Database)TF
DoCM (Curated mutations)TF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TF (select a term)
intoGenTF
Cancer3DTF(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190000    209300   
Orphanet795   
DisGeNETTF
MedgenTF
Genetic Testing Registry TF
NextProtP02787 [Medical]
TSGene7018
GENETestsTF
Target ValidationTF
Huge Navigator TF [HugePedia]
snp3D : Map Gene to Disease7018
BioCentury BCIQTF
ClinGenTF
Clinical trials, drugs, therapy
Protein Interactions : CTD7018
Pharm GKB GenePA36457
Clinical trialTF
Miscellaneous
canSAR (ICR)TF (select the gene name)
HarmonizomeTF
DataMed IndexTF
Probes
Litterature
PubMed377 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTF
EVEXTF
GoPubMedTF
iHOPTF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Jun 30 20:33:37 CEST 2020

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