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TFAM (transcription factor A, mitochondrial)

Identity

Alias_namesTCF6
TCF6L2
Other aliasMTDPS15
MTTF1
MTTFA
TCF6L1
TCF6L3
HGNC (Hugo) TFAM
LocusID (NCBI) 7019
Atlas_Id 52068
Location 10q21.1  [Link to chromosome band 10q21]
Location_base_pair Starts at 58385143 and ends at 58399230 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP8B3 (19p13.3) / TFAM (10q21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TFAM   11741
Cards
Entrez_Gene (NCBI)TFAM  7019  transcription factor A, mitochondrial
AliasesMTDPS15; MTTF1; MTTFA; TCF6; 
TCF6L1; TCF6L2; TCF6L3
GeneCards (Weizmann)TFAM
Ensembl hg19 (Hinxton)ENSG00000108064 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108064 [Gene_View]  ENSG00000108064 [Sequence]  chr10:58385143-58399230 [Contig_View]  TFAM [Vega]
ICGC DataPortalENSG00000108064
TCGA cBioPortalTFAM
AceView (NCBI)TFAM
Genatlas (Paris)TFAM
WikiGenes7019
SOURCE (Princeton)TFAM
Genetics Home Reference (NIH)TFAM
Genomic and cartography
GoldenPath hg38 (UCSC)TFAM  -     chr10:58385143-58399230 +  10q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFAM  -     10q21.1   [Description]    (hg19-Feb_2009)
GoldenPathTFAM - 10q21.1 [CytoView hg19]  TFAM - 10q21.1 [CytoView hg38]
ImmunoBaseENSG00000108064
Mapping of homologs : NCBITFAM [Mapview hg19]  TFAM [Mapview hg38]
OMIM600438   617156   
Gene and transcription
Genbank (Entrez)AB451241 AB451366 AK312558 BC018628 BC029815
RefSeq transcript (Entrez)NM_001270782 NM_003201 NM_012251
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TFAM
Cluster EST : UnigeneHs.594250 [ NCBI ]
CGAP (NCI)Hs.594250
Alternative Splicing GalleryENSG00000108064
Gene ExpressionTFAM [ NCBI-GEO ]   TFAM [ EBI - ARRAY_EXPRESS ]   TFAM [ SEEK ]   TFAM [ MEM ]
Gene Expression Viewer (FireBrowse)TFAM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7019
GTEX Portal (Tissue expression)TFAM
Human Protein AtlasENSG00000108064-TFAM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00059   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00059  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00059
Splice isoforms : SwissVarQ00059
PhosPhoSitePlusQ00059
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)HMG_box_dom    HMG_box_dom_sf   
Domain families : Pfam (Sanger)HMG_box (PF00505)    HMG_box_2 (PF09011)   
Domain families : Pfam (NCBI)pfam00505    pfam09011   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)TFAM
DMDM Disease mutations7019
Blocks (Seattle)TFAM
PDB (RSDB)3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ   
PDB Europe3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ   
PDB (PDBSum)3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ   
PDB (IMB)3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ   
Structural Biology KnowledgeBase3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ   
SCOP (Structural Classification of Proteins)3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ   
CATH (Classification of proteins structures)3FGH    3TMM    3TQ6    4NNU    4NOD    6ERP    6ERQ   
SuperfamilyQ00059
Human Protein Atlas [tissue]ENSG00000108064-TFAM [tissue]
Peptide AtlasQ00059
HPRD02702
IPIIPI00020928   IPI01018732   IPI00643708   IPI00644515   
Protein Interaction databases
DIP (DOE-UCLA)Q00059
IntAct (EBI)Q00059
FunCoupENSG00000108064
BioGRIDTFAM
STRING (EMBL)TFAM
ZODIACTFAM
Ontologies - Pathways
QuickGOQ00059
Ontology : AmiGOmitochondrial promoter sequence-specific DNA binding  transcription coactivator binding  chromatin binding  DNA-binding transcription factor activity  RNA binding  protein binding  nucleus  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  mitochondrial transcription  transcription initiation from mitochondrial promoter  transcription initiation from mitochondrial promoter  mitochondrion organization  DNA binding, bending  heat shock protein binding  protein-containing complex  mitochondrial respiratory chain complex assembly  mitochondrial nucleoid  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  
Ontology : EGO-EBImitochondrial promoter sequence-specific DNA binding  transcription coactivator binding  chromatin binding  DNA-binding transcription factor activity  RNA binding  protein binding  nucleus  mitochondrion  mitochondrial matrix  mitochondrial matrix  cytosol  mitochondrial transcription  transcription initiation from mitochondrial promoter  transcription initiation from mitochondrial promoter  mitochondrion organization  DNA binding, bending  heat shock protein binding  protein-containing complex  mitochondrial respiratory chain complex assembly  mitochondrial nucleoid  sequence-specific DNA binding  positive regulation of transcription, DNA-templated  
Pathways : KEGGHuntington's disease   
NDEx NetworkTFAM
Atlas of Cancer Signalling NetworkTFAM
Wikipedia pathwaysTFAM
Orthology - Evolution
OrthoDB7019
GeneTree (enSembl)ENSG00000108064
Phylogenetic Trees/Animal Genes : TreeFamTFAM
HOGENOMQ00059
Homologs : HomoloGeneTFAM
Homology/Alignments : Family Browser (UCSC)TFAM
Gene fusions - Rearrangements
Fusion : QuiverTFAM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFAM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TFAM
dbVarTFAM
ClinVarTFAM
1000_GenomesTFAM 
Exome Variant ServerTFAM
ExAC (Exome Aggregation Consortium)ENSG00000108064
GNOMAD BrowserENSG00000108064
Varsome BrowserTFAM
Genetic variants : HAPMAP7019
Genomic Variants (DGV)TFAM [DGVbeta]
DECIPHERTFAM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFAM 
Mutations
ICGC Data PortalTFAM 
TCGA Data PortalTFAM 
Broad Tumor PortalTFAM
OASIS PortalTFAM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFAM  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTFAM
Mutations and Diseases : HGMDTFAM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TFAM
DgiDB (Drug Gene Interaction Database)TFAM
DoCM (Curated mutations)TFAM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TFAM (select a term)
intoGenTFAM
Cancer3DTFAM(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600438    617156   
Orphanet
DisGeNETTFAM
MedgenTFAM
Genetic Testing Registry TFAM
NextProtQ00059 [Medical]
TSGene7019
GENETestsTFAM
Target ValidationTFAM
Huge Navigator TFAM [HugePedia]
snp3D : Map Gene to Disease7019
BioCentury BCIQTFAM
ClinGenTFAM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7019
Chemical/Pharm GKB GenePA36458
Clinical trialTFAM
Miscellaneous
canSAR (ICR)TFAM (select the gene name)
DataMed IndexTFAM
Probes
Litterature
PubMed205 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTFAM
EVEXTFAM
GoPubMedTFAM
iHOPTFAM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:11:28 CET 2019
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