TGFA (transforming growth factor alpha)

2003-02-01  

Identity

HGNC
LOCATION
2p13.3
LOCUSID
ALIAS
TFGA
FUSION GENES

Other Information

Locus ID:

NCBI: 7039
MIM: 190170
HGNC: 11765
Ensembl: ENSG00000163235

Variants:

dbSNP: 7039
ClinVar: 7039
TCGA: ENSG00000163235
COSMIC: TGFA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163235ENST00000295400P01135
ENSG00000163235ENST00000394241F8WA74
ENSG00000163235ENST00000418333P01135
ENSG00000163235ENST00000419940H0Y6S5
ENSG00000163235ENST00000444975F8VNR3
ENSG00000163235ENST00000445399P01135
ENSG00000163235ENST00000450929E7EPT6

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Renal cell carcinomaKEGGko05211
Pancreatic cancerKEGGko05212
GliomaKEGGko05214
Prostate cancerKEGGko05215
Non-small cell lung cancerKEGGko05223
ErbB signaling pathwayKEGGhsa04012
Pathways in cancerKEGGhsa05200
Renal cell carcinomaKEGGhsa05211
Pancreatic cancerKEGGhsa05212
GliomaKEGGhsa05214
Prostate cancerKEGGhsa05215
Non-small cell lung cancerKEGGhsa05223
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Cargo concentration in the ERREACTOMER-HSA-5694530
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsREACTOMER-HSA-8866910

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10040cetuximabChemicalPathwayassociated
PA162373091panitumumabChemicalPathwayassociated

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
241227932013Increased TGF-α as a mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells.59
126063072003Bile acids activate EGF receptor via a TGF-alpha-dependent mechanism in human cholangiocyte cell lines.50
197491562009G protein-coupled receptor 30 expression is up-regulated by EGF and TGF alpha in estrogen receptor alpha-positive cancer cells.49
179622082008ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis.46
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
158791092005TGF-alpha regulates TLR expression and function on epidermal keratinocytes.42
192442012009Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.42
126190352003Hepatocyte growth factor, transforming growth factor alpha, and their receptors as combined markers of prognosis in hepatocellular carcinoma.41

Citation

Dessen P

TGFA (transforming growth factor alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/32/tgfa