Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TGFB1 (transforming growth factor, beta 1)

Identity

Other namesCED
DPD1
LAP
TGFB
TGFbeta
HGNC (Hugo) TGFB1
LocusID (NCBI) 7040
Location 19q13.2
Location_base_pair Starts at 41836812 and ends at 41859831 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TGFB1   11766
Entrez_Gene (NCBI)TGFB1  7040  transforming growth factor, beta 1
Cards
GeneCards (Weizmann)TGFB1
Ensembl (Hinxton)ENSG00000105329 [Gene_View]  chr19:41836812-41859831 [Contig_View]  TGFB1 [Vega]
AceView (NCBI)TGFB1
Genatlas (Paris)TGFB1
SOURCE (Stanford)NM_000660
Genomic and cartography
GoldenPath (UCSC)TGFB1  -  19q13.2   chr19:41836812-41859831 -  19q13.2   [Description]    (hg19-Feb_2009)
EnsemblTGFB1 - 19q13.2 [CytoView]
Mapping of homologs : NCBITGFB1 [Mapview]
OMIM131300   190180   219700   
Gene and transcription
Genbank (Entrez)AI304490 AK291907 AK307742 AY820829 BC000125
RefSeq transcript (SRS)NM_000660
RefSeq transcript (Entrez)NM_000660
RefSeq genomic (SRS)AC_000151 NC_000019 NC_018930 NG_013364 NT_011109 NW_001838496 NW_004078099
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_013364 NT_011109 NW_001838496 NW_004078099
Consensus coding sequences : CCDS (NCBI)TGFB1
Cluster EST : UnigeneHs.645227 [ SRS ] Hs.645227 [ NCBI ]
CGAP (NCI)Hs.645227
Alternative Splicing : Fast-db (Paris)GSHG0015842
Alternative Splicing GalleryENSG00000105329
Gene ExpressionTGFB1 [ NCBI-GEO ]   TGFB1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01137 (SRS) P01137 (Uniprot)
NextProtP01137
With graphics : InterProP01137
Splice isoforms : SwissVarP01137(Swissvar)
Domaine pattern : Prosite (SRS)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (SRS)TGF-b_C    TGF-b_N    TGF-beta    TGF-beta-rel    TGFb1    TGFb_CS   
Domains : Interpro (EBI)TGF-b_C    TGF-b_N    TGF-beta    TGF-beta-rel    TGFb1    TGFb_CS   
Related proteins : CluSTrP01137
Domain families : Pfam (SRS)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
DMDM7040
Blocks (Seattle)P01137
PDB (SRS)1KLA    1KLC    1KLD    3KFD   
PDB (PDBSum)1KLA    1KLC    1KLD    3KFD   
PDB (IMB)1KLA    1KLC    1KLD    3KFD   
PDB (RSDB)1KLA    1KLC    1KLD    3KFD   
Human Protein AtlasENSG00000105329
HPRD01821
IPIIPI00000075   
Protein Interaction databases
DIP (DOE-UCLA)P01137
IntAct (EBI)P01137
FunCoupENSG00000105329
REACTOMETGFB1
Protein Interaction Database7040
BioGRIDTGFB1
InParanoidP01137
Interologous Interaction database P01137
IntegromeDBTGFB1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TGFB1
SNP (GeneSNP Utah)TGFB1
SNP : HGBaseTGFB1
Genetic variants : HAPMAPTGFB1
Somatic Mutations in Cancer : COSMICTGFB1 
CONAN: Copy Number AnalysisTGFB1 
Mutations and Diseases : HGMDTGFB1
OMIM131300    190180    219700   
GENETests131300    190180    219700   
Disease Genetic AssociationTGFB1
Huge Navigator TGFB1 [HugePedia]  TGFB1 [HugeCancerGEM]
Genomic VariantsTGFB1  TGFB1 [DGVbeta]
snp3D : Map Gene to Disease7040
General knowledge
Homologs : HomoloGeneTGFB1
Homology/Alignments : Family Browser (UCSC)TGFB1
Phylogenetic Trees/Animal Genes : TreeFamTGFB1
Chemical/Protein Interactions : CTD7040
Chemical/Pharm GKB GenePA350
Clinical trialTGFB1
Cancer Resource (Charite)ENSG00000105329
Ontology : AmiGOprotein import into nucleus, translocation  negative regulation of transcription from RNA polymerase II promoter  MAPK cascade  ureteric bud development  response to hypoxia  epithelial to mesenchymal transition  negative regulation of protein phosphorylation  positive regulation of protein phosphorylation  regulation of sodium ion transport  chondrocyte differentiation  hematopoietic progenitor cell differentiation  connective tissue replacement involved in inflammatory response wound healing  adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains  tolerance induction to self antigen  platelet degranulation  type II transforming growth factor beta receptor binding  type II transforming growth factor beta receptor binding  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  nucleus  cytoplasm  Golgi lumen  microvillus  protein phosphorylation  protein export from nucleus  ATP biosynthetic process  phosphate-containing compound metabolic process  cellular calcium ion homeostasis  induction of apoptosis  inflammatory response  inflammatory response  cell cycle arrest  epidermal growth factor receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  SMAD protein complex assembly  SMAD protein import into nucleus  negative regulation of neuroblast proliferation  salivary gland morphogenesis  endoderm development  female pregnancy  aging  blood coagulation  growth factor activity  negative regulation of DNA replication  cell death  positive regulation of cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  germ cell migration  response to radiation  response to wounding  response to glucose stimulus  embryo development  defense response to fungus, incompatible interaction  cell surface  positive regulation vascular endothelial growth factor production  positive regulation of gene expression  positive regulation of epithelial to mesenchymal transition  positive regulation of epithelial to mesenchymal transition  macrophage derived foam cell differentiation  positive regulation of fibroblast migration  positive regulation of peptidyl-threonine phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  negative regulation of macrophage cytokine production  cell growth  regulation of striated muscle tissue development  regulation of transforming growth factor beta receptor signaling pathway  virus-host interaction  evasion or tolerance of host defenses by virus  viral infectious cycle  enzyme binding  negative regulation of cell-cell adhesion  platelet activation  hyaluronan catabolic process  negative regulation of ossification  negative regulation of cell growth  regulation of cell migration  positive regulation of cell migration  axon  positive regulation of bone mineralization  negative regulation of transforming growth factor beta receptor signaling pathway  positive regulation of histone deacetylation  platelet alpha granule lumen  organ regeneration  positive regulation of protein complex assembly  positive regulation of exit from mitosis  mitotic cell cycle G1/S transition checkpoint  lipopolysaccharide-mediated signaling pathway  positive regulation of cellular protein metabolic process  response to estradiol stimulus  response to progesterone stimulus  positive regulation of interleukin-17 production  receptor catabolic process  positive regulation of superoxide anion generation  mononuclear cell proliferation  positive regulation of collagen biosynthetic process  positive regulation of collagen biosynthetic process  positive regulation of peptidyl-serine phosphorylation  response to vitamin D  response to laminar fluid shear stress  positive regulation of histone acetylation  positive regulation of protein dephosphorylation  negative regulation of T cell proliferation  regulation of protein import into nucleus  positive regulation of protein import into nucleus  positive regulation of odontogenesis  response to drug  myelination  protein homodimerization activity  myeloid dendritic cell differentiation  neuronal cell body  T cell homeostasis  positive regulation of MAP kinase activity  protein kinase B signaling cascade  eukaryotic cell surface binding  positive regulation of blood vessel endothelial cell migration  negative regulation of blood vessel endothelial cell migration  positive regulation of phosphatidylinositol 3-kinase activity  ossification involved in bone remodeling  regulatory T cell differentiation  cell-cell junction organization  negative regulation of fat cell differentiation  negative regulation of myoblast differentiation  negative regulation of cell cycle  negative regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  negative regulation of mitotic cell cycle  positive regulation of transcription from RNA polymerase II promoter  active induction of host immune response by virus  protein heterodimerization activity  protein N-terminus binding  positive regulation of isotype switching to IgA isotypes  lymph node development  digestive tract development  negative regulation of skeletal muscle tissue development  inner ear development  positive regulation of epithelial cell proliferation  negative regulation of epithelial cell proliferation  negative regulation of epithelial cell proliferation  positive regulation of protein secretion  negative regulation of phagocytosis  negative regulation of immune response  positive regulation of chemotaxis  positive regulation of NF-kappaB transcription factor activity  regulation of binding  regulation of DNA binding  positive regulation of smooth muscle cell differentiation  negative regulation of release of sequestered calcium ion into cytosol  positive regulation of cell division  positive regulation of protein kinase B signaling cascade  face morphogenesis  frontal suture morphogenesis  pathway-restricted SMAD protein phosphorylation  positive regulation of SMAD protein import into nucleus  mammary gland branching involved in thelarche  branch elongation involved in mammary gland duct branching  regulation of branching involved in mammary gland duct morphogenesis  regulation of cartilage development  lens fiber cell differentiation  response to cholesterol  positive regulation of cell cycle arrest  cellular response to organic cyclic compound  cellular response to dexamethasone stimulus  extracellular matrix assembly  positive regulation of branching involved in ureteric bud morphogenesis  negative regulation of hyaluronan biosynthetic process  positive regulation of NAD+ ADP-ribosyltransferase activity  positive regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBIprotein import into nucleus, translocation  negative regulation of transcription from RNA polymerase II promoter  MAPK cascade  ureteric bud development  response to hypoxia  epithelial to mesenchymal transition  negative regulation of protein phosphorylation  positive regulation of protein phosphorylation  regulation of sodium ion transport  chondrocyte differentiation  hematopoietic progenitor cell differentiation  connective tissue replacement involved in inflammatory response wound healing  adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains  tolerance induction to self antigen  platelet degranulation  type II transforming growth factor beta receptor binding  type II transforming growth factor beta receptor binding  protein binding  extracellular region  proteinaceous extracellular matrix  extracellular space  nucleus  cytoplasm  Golgi lumen  microvillus  protein phosphorylation  protein export from nucleus  ATP biosynthetic process  phosphate-containing compound metabolic process  cellular calcium ion homeostasis  induction of apoptosis  inflammatory response  inflammatory response  cell cycle arrest  epidermal growth factor receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  SMAD protein complex assembly  SMAD protein import into nucleus  negative regulation of neuroblast proliferation  salivary gland morphogenesis  endoderm development  female pregnancy  aging  blood coagulation  growth factor activity  negative regulation of DNA replication  cell death  positive regulation of cell proliferation  positive regulation of cell proliferation  negative regulation of cell proliferation  germ cell migration  response to radiation  response to wounding  response to glucose stimulus  embryo development  defense response to fungus, incompatible interaction  cell surface  positive regulation vascular endothelial growth factor production  positive regulation of gene expression  positive regulation of epithelial to mesenchymal transition  positive regulation of epithelial to mesenchymal transition  macrophage derived foam cell differentiation  positive regulation of fibroblast migration  positive regulation of peptidyl-threonine phosphorylation  positive regulation of pathway-restricted SMAD protein phosphorylation  negative regulation of macrophage cytokine production  cell growth  regulation of striated muscle tissue development  regulation of transforming growth factor beta receptor signaling pathway  virus-host interaction  evasion or tolerance of host defenses by virus  viral infectious cycle  enzyme binding  negative regulation of cell-cell adhesion  platelet activation  hyaluronan catabolic process  negative regulation of ossification  negative regulation of cell growth  regulation of cell migration  positive regulation of cell migration  axon  positive regulation of bone mineralization  negative regulation of transforming growth factor beta receptor signaling pathway  positive regulation of histone deacetylation  platelet alpha granule lumen  organ regeneration  positive regulation of protein complex assembly  positive regulation of exit from mitosis  mitotic cell cycle G1/S transition checkpoint  lipopolysaccharide-mediated signaling pathway  positive regulation of cellular protein metabolic process  response to estradiol stimulus  response to progesterone stimulus  positive regulation of interleukin-17 production  receptor catabolic process  positive regulation of superoxide anion generation  mononuclear cell proliferation  positive regulation of collagen biosynthetic process  positive regulation of collagen biosynthetic process  positive regulation of peptidyl-serine phosphorylation  response to vitamin D  response to laminar fluid shear stress  positive regulation of histone acetylation  positive regulation of protein dephosphorylation  negative regulation of T cell proliferation  regulation of protein import into nucleus  positive regulation of protein import into nucleus  positive regulation of odontogenesis  response to drug  myelination  protein homodimerization activity  myeloid dendritic cell differentiation  neuronal cell body  T cell homeostasis  positive regulation of MAP kinase activity  protein kinase B signaling cascade  eukaryotic cell surface binding  positive regulation of blood vessel endothelial cell migration  negative regulation of blood vessel endothelial cell migration  positive regulation of phosphatidylinositol 3-kinase activity  ossification involved in bone remodeling  regulatory T cell differentiation  cell-cell junction organization  negative regulation of fat cell differentiation  negative regulation of myoblast differentiation  negative regulation of cell cycle  negative regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  positive regulation of transcription, DNA-dependent  negative regulation of mitotic cell cycle  positive regulation of transcription from RNA polymerase II promoter  active induction of host immune response by virus  protein heterodimerization activity  protein N-terminus binding  positive regulation of isotype switching to IgA isotypes  lymph node development  digestive tract development  negative regulation of skeletal muscle tissue development  inner ear development  positive regulation of epithelial cell proliferation  negative regulation of epithelial cell proliferation  negative regulation of epithelial cell proliferation  positive regulation of protein secretion  negative regulation of phagocytosis  negative regulation of immune response  positive regulation of chemotaxis  positive regulation of NF-kappaB transcription factor activity  regulation of binding  regulation of DNA binding  positive regulation of smooth muscle cell differentiation  negative regulation of release of sequestered calcium ion into cytosol  positive regulation of cell division  positive regulation of protein kinase B signaling cascade  face morphogenesis  frontal suture morphogenesis  pathway-restricted SMAD protein phosphorylation  positive regulation of SMAD protein import into nucleus  mammary gland branching involved in thelarche  branch elongation involved in mammary gland duct branching  regulation of branching involved in mammary gland duct morphogenesis  regulation of cartilage development  lens fiber cell differentiation  response to cholesterol  positive regulation of cell cycle arrest  cellular response to organic cyclic compound  cellular response to dexamethasone stimulus  extracellular matrix assembly  positive regulation of branching involved in ureteric bud morphogenesis  negative regulation of hyaluronan biosynthetic process  positive regulation of NAD+ ADP-ribosyltransferase activity  positive regulation of transcription regulatory region DNA binding  
Pathways : BIOCARTAp38 MAPK Signaling Pathway [Genes]    Erythrocyte Differentiation Pathway [Genes]    Cytokines and Inflammatory Response [Genes]    MAPKinase Signaling Pathway [Genes]    TGF beta signaling pathway [Genes]    Role of Tob in T-cell activation [Genes]    ALK in cardiac myocytes [Genes]    CTCF: First Multivalent Nuclear Factor [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]    Function of SLRP in Bone: An Integrated View [Genes]    Cell Cycle: G1/S Check Point [Genes]    Signal transduction through IL1R [Genes]   
Pathways : KEGGTGF-beta signaling pathwayColorectal cancerMAPK signaling pathwayCell cycleCytokine-cytokine receptor interaction
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
PubGeneTGFB1
iHOPTGFB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:47:03 CEST 2013
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