TGIF1 (TGFB induced factor homeobox 1)

2007-02-01  

Identity

HGNC
TGIF1
LOCATION
18p11.31
LOCUSID
7050
ALIAS
HPE4,TGIF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7050
MIM: 602630
HGNC: 11776
Ensembl: ENSG00000177426

Variants:

dbSNP: 7050
ClinVar: 7050
TCGA: ENSG00000177426
COSMIC: TGIF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177426ENST00000330513Q15583
ENSG00000177426ENST00000343820Q15583
ENSG00000177426ENST00000345133Q15583
ENSG00000177426ENST00000400167Q15583
ENSG00000177426ENST00000401449Q15583
ENSG00000177426ENST00000405385Q15583
ENSG00000177426ENST00000407501Q15583
ENSG00000177426ENST00000472042Q15583
ENSG00000177426ENST00000546979F8VYL4
ENSG00000177426ENST00000548489Q15583
ENSG00000177426ENST00000549253F8VXG3
ENSG00000177426ENST00000549468F8VX54
ENSG00000177426ENST00000549546F8VVS9
ENSG00000177426ENST00000549780F8VUY0
ENSG00000177426ENST00000550958F8VW34
ENSG00000177426ENST00000551333F8VZH2
ENSG00000177426ENST00000551402F8W1J9
ENSG00000177426ENST00000551541Q15583
ENSG00000177426ENST00000552383F8VWK5
ENSG00000177426ENST00000577543J3KS32
ENSG00000177426ENST00000618001Q15583

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Downregulation of SMAD2/3:SMAD4 transcriptional activityREACTOMER-HSA-2173795
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

References

Pubmed IDYearTitleCitations
230193442012Overcoming transcription activator-like effector (TALE) DNA binding domain sensitivity to cytosine methylation.69
219407352011New findings for phenotype-genotype correlations in a large European series of holoprosencephaly cases.29
169166422006Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling.25
215770132011Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles.25
206229012010Tumor suppressor Fbxw7 regulates TGFβ signaling by targeting TGIF1 for degradation.22
169623542007Functional analysis of mutations in TGIF associated with holoprosencephaly.20
126010222003TGFbeta-induced factor: a candidate gene for high myopia.19
196991592009Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells.19
190602652009High myopia is not associated with the SNPs in the TGIF, lumican, TGFB1, and HGF genes.18
190602652009High myopia is not associated with the SNPs in the TGIF, lumican, TGFB1, and HGF genes.18

Citation

Dessen P

TGIF1 (TGFB induced factor homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46146/tgif1