Atlas of Genetics and Cytogenetics in Oncology and Haematology

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THBS3 (thrombospondin 3)

Identity

Other aliasTSP3
HGNC (Hugo) THBS3
LocusID (NCBI) 7059
Atlas_Id 42550
Location 1q22  [Link to chromosome band 1q22]
Location_base_pair Starts at 155195588 and ends at 155207981 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTB (7p22.1) / THBS3 (1q22)ARID1A (1p36.11) / THBS3 (1q22)CHI3L1 (1q32.1) / THBS3 (1q22)
COMT (22q11.21) / THBS3 (1q22)NRN1 (6p25.1) / THBS3 (1q22)PSAP (10q22.1) / THBS3 (1q22)
THBS3 (1q22) / FBXW11 (5q35.1)ARID1A 1p36.11 / THBS3 1q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;1)(p36;q22) ARID1A/THBS3

External links

Nomenclature
HGNC (Hugo)THBS3   11787
Cards
Entrez_Gene (NCBI)THBS3  7059  thrombospondin 3
AliasesTSP3
GeneCards (Weizmann)THBS3
Ensembl hg19 (Hinxton)ENSG00000169231 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169231 [Gene_View]  ENSG00000169231 [Sequence]  chr1:155195588-155207981 [Contig_View]  THBS3 [Vega]
ICGC DataPortalENSG00000169231
TCGA cBioPortalTHBS3
AceView (NCBI)THBS3
Genatlas (Paris)THBS3
WikiGenes7059
SOURCE (Princeton)THBS3
Genetics Home Reference (NIH)THBS3
Genomic and cartography
GoldenPath hg38 (UCSC)THBS3  -     chr1:155195588-155207981 -  1q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)THBS3  -     1q22   [Description]    (hg19-Feb_2009)
GoldenPathTHBS3 - 1q22 [CytoView hg19]  THBS3 - 1q22 [CytoView hg38]
ImmunoBaseENSG00000169231
Mapping of homologs : NCBITHBS3 [Mapview hg19]  THBS3 [Mapview hg38]
OMIM188062   
Gene and transcription
Genbank (Entrez)AK074796 AK223278 AK298592 AK298803 AK298914
RefSeq transcript (Entrez)NM_001252607 NM_001252608 NM_007112
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)THBS3
Cluster EST : UnigeneHs.658188 [ NCBI ]
CGAP (NCI)Hs.658188
Alternative Splicing GalleryENSG00000169231
Gene ExpressionTHBS3 [ NCBI-GEO ]   THBS3 [ EBI - ARRAY_EXPRESS ]   THBS3 [ SEEK ]   THBS3 [ MEM ]
Gene Expression Viewer (FireBrowse)THBS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7059
GTEX Portal (Tissue expression)THBS3
Human Protein AtlasENSG00000169231-THBS3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49746   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49746  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49746
Splice isoforms : SwissVarP49746
PhosPhoSitePlusP49746
Domaine pattern : Prosite (Expaxy)EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    TSP3 (PS51234)    TSP_CTER (PS51236)   
Domains : Interpro (EBI)ConA-like_dom_sf    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF_Ca-bd_CS    Laminin_G    Thbs/COMP_coiled-coil    Thrombospondin    Thrombospondin-3    Thrombospondin_3-like_rpt    Thrombospondin_3_rpt    Thrombospondin_C    TSP_type-3_rpt   
Domain families : Pfam (Sanger)COMP (PF11598)    EGF_CA (PF07645)    TSP_3 (PF02412)    TSP_C (PF05735)   
Domain families : Pfam (NCBI)pfam11598    pfam07645    pfam02412    pfam05735   
Domain families : Smart (EMBL)EGF (SM00181)  EGF_CA (SM00179)  TSPN (SM00210)  
Conserved Domain (NCBI)THBS3
DMDM Disease mutations7059
Blocks (Seattle)THBS3
SuperfamilyP49746
Human Protein Atlas [tissue]ENSG00000169231-THBS3 [tissue]
Peptide AtlasP49746
HPRD01767
IPIIPI00329535   IPI01009251   IPI00909549   IPI01009661   IPI01010083   
Protein Interaction databases
DIP (DOE-UCLA)P49746
IntAct (EBI)P49746
FunCoupENSG00000169231
BioGRIDTHBS3
STRING (EMBL)THBS3
ZODIACTHBS3
Ontologies - Pathways
QuickGOP49746
Ontology : AmiGOgrowth plate cartilage development  extracellular matrix structural constituent  calcium ion binding  extracellular region  cell-matrix adhesion  heparin binding  ossification involved in bone maturation  perinuclear region of cytoplasm  bone trabecula formation  collagen-containing extracellular matrix  collagen-containing extracellular matrix  
Ontology : EGO-EBIgrowth plate cartilage development  extracellular matrix structural constituent  calcium ion binding  extracellular region  cell-matrix adhesion  heparin binding  ossification involved in bone maturation  perinuclear region of cytoplasm  bone trabecula formation  collagen-containing extracellular matrix  collagen-containing extracellular matrix  
Pathways : KEGGPhagosome    PI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    Malaria   
NDEx NetworkTHBS3
Atlas of Cancer Signalling NetworkTHBS3
Wikipedia pathwaysTHBS3
Orthology - Evolution
OrthoDB7059
GeneTree (enSembl)ENSG00000169231
Phylogenetic Trees/Animal Genes : TreeFamTHBS3
HOGENOMP49746
Homologs : HomoloGeneTHBS3
Homology/Alignments : Family Browser (UCSC)THBS3
Gene fusions - Rearrangements
Fusion : MitelmanARID1A/THBS3 [1p36.11/1q22]  [t(1;1)(p36;q22)]  
Fusion PortalARID1A 1p36.11 THBS3 1q22 BRCA
Fusion : QuiverTHBS3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTHBS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)THBS3
dbVarTHBS3
ClinVarTHBS3
1000_GenomesTHBS3 
Exome Variant ServerTHBS3
ExAC (Exome Aggregation Consortium)ENSG00000169231
GNOMAD BrowserENSG00000169231
Varsome BrowserTHBS3
Genetic variants : HAPMAP7059
Genomic Variants (DGV)THBS3 [DGVbeta]
DECIPHERTHBS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTHBS3 
Mutations
ICGC Data PortalTHBS3 
TCGA Data PortalTHBS3 
Broad Tumor PortalTHBS3
OASIS PortalTHBS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTHBS3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTHBS3
Mutations and Diseases : HGMDTHBS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch THBS3
DgiDB (Drug Gene Interaction Database)THBS3
DoCM (Curated mutations)THBS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)THBS3 (select a term)
intoGenTHBS3
Cancer3DTHBS3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188062   
Orphanet
DisGeNETTHBS3
MedgenTHBS3
Genetic Testing Registry THBS3
NextProtP49746 [Medical]
TSGene7059
GENETestsTHBS3
Target ValidationTHBS3
Huge Navigator THBS3 [HugePedia]
snp3D : Map Gene to Disease7059
BioCentury BCIQTHBS3
ClinGenTHBS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7059
Chemical/Pharm GKB GenePA36499
Clinical trialTHBS3
Miscellaneous
canSAR (ICR)THBS3 (select the gene name)
DataMed IndexTHBS3
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTHBS3
EVEXTHBS3
GoPubMedTHBS3
iHOPTHBS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:11:37 CET 2019
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