THOP1 (thimet oligopeptidase 1)

2015-02-01  

Identity

HGNC
THOP1
LOCATION
19p13.3
LOCUSID
7064
ALIAS
EP24.15,MEPD_HUMAN,MP78,TOP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7064
MIM: 601117
HGNC: 11793
Ensembl: ENSG00000172009

Variants:

dbSNP: 7064
ClinVar: 7064
TCGA: ENSG00000172009
COSMIC: THOP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172009ENST00000307741P52888
ENSG00000172009ENST00000585338K7EKB6
ENSG00000172009ENST00000586677K7EP46
ENSG00000172009ENST00000587401K7EL32
ENSG00000172009ENST00000587468K7EIK4
ENSG00000172009ENST00000590970K7EL02
ENSG00000172009ENST00000591363K7EMU4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Renin-angiotensin systemKEGGko04614
Renin-angiotensin systemKEGGhsa04614
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
153283612004Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases.59
211511012011Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.43
192822852009Analysis of intracellular substrates and products of thimet oligopeptidase in human embryonic kidney 293 cells.29
149989932004Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization.27
185711002008Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity.14
227961132012Inhibition of thimet oligopeptidase by siRNA alters specific intracellular peptides and potentiates isoproterenol signal transduction.9
172511852007Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase.7
246045812014Expression analysis of THOP1 in background liver, a prognostic predictive factor in hepatocellular carcinoma, extracted by multiarray analysis.6
153762292005EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor.5
251809102014Expression of THOP1 and its relationship to prognosis in non-small cell lung cancer.5

Citation

Dessen P

THOP1 (thimet oligopeptidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55021/thop1