Identity
HGNC
LOCATION
2p13.3
LOCUSID
ALIAS
ALS26,TIA-1,WDM
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7072
MIM: 603518
HGNC: 11802
Ensembl: ENSG00000116001
Variants:
dbSNP: 7072
ClinVar: 7072
TCGA: ENSG00000116001
COSMIC: TIA1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by FGFR | REACTOME | R-HSA-190236 |
| Signaling by FGFR2 | REACTOME | R-HSA-5654738 |
| FGFR2 alternative splicing | REACTOME | R-HSA-6803529 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38858355 | 2024 | The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics. | 0 |
| 38858355 | 2024 | The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics. | 0 |
| 37349329 | 2023 | Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein. | 3 |
| 38016875 | 2023 | Distal myopathy due to digenic inheritance of TIA1 and SQSTM1 variants in two unrelated Spanish patients. | 0 |
| 38279501 | 2023 | RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer. | 0 |
| 37349329 | 2023 | Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein. | 3 |
| 38016875 | 2023 | Distal myopathy due to digenic inheritance of TIA1 and SQSTM1 variants in two unrelated Spanish patients. | 0 |
| 38279501 | 2023 | RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer. | 0 |
| 34750982 | 2022 | Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1. | 9 |
| 35163320 | 2022 | The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease. | 6 |
| 35799293 | 2022 | Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling. | 6 |
| 35872367 | 2022 | The role of peritumoral CD8 + /TIA1 + lymphocytes in hepatocellular carcinoma aggressiveness and recurrence after surgical resection. | 0 |
| 36112647 | 2022 | ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures. | 6 |
| 34750982 | 2022 | Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1. | 9 |
| 35163320 | 2022 | The Multifunctional Faces of T-Cell Intracellular Antigen 1 in Health and Disease. | 6 |
Citation
Dessen P
TIA1 (TIA1 cytotoxic granule associated RNA binding protein)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46551/tia1
