TIA1 (TIA1 cytotoxic granule associated RNA binding protein)

2007-02-01 Affiliation

Identity

HGNC

TIA1

LOCATION

2p13.3

LOCUSID

7072

ALIAS

ALS26,TIA-1,WDM

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7072
MIM: 603518
HGNC: 11802
Ensembl: ENSG00000116001

Variants:

dbSNP: 7072
ClinVar: 7072
TCGA: ENSG00000116001
COSMIC: TIA1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116001	ENST00000282574	F8W8I6
ENSG00000116001	ENST00000361692	H7BY49
ENSG00000116001	ENST00000415783	P31483
ENSG00000116001	ENST00000416149	P31483
ENSG00000116001	ENST00000433529	P31483
ENSG00000116001	ENST00000445587	C9JTN7
ENSG00000116001	ENST00000454815	F8WE16
ENSG00000116001	ENST00000474809	E5RGV5
ENSG00000116001	ENST00000477044	E5RG67

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR2	REACTOME	R-HSA-5654738
FGFR2 alternative splicing	REACTOME	R-HSA-6803529

References

Pubmed ID	Year	Title	Citations
21257637	2011	TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.	139
19641607	2009	Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors.	127
28817800	2017	TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.	125
16227602	2005	Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1.	123
11106748	2000	The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing.	120
21048981	2010	iCLIP predicts the dual splicing effects of TIA-RNA interactions.	117
12486009	2002	The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites.	101
18775331	2008	Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival.	70
12885872	2003	Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1.	68
15280467	2004	Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs.	53

Citation

Dessen P

TIA1 (TIA1 cytotoxic granule associated RNA binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46551/tia1