TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1)

2007-02-01  

Identity

HGNC
TIAL1
LOCATION
10q26.11
LOCUSID
7073
ALIAS
TCBP,TIAR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7073
MIM: 603413
HGNC: 11804
Ensembl: ENSG00000151923

Variants:

dbSNP: 7073
ClinVar: 7073
TCGA: ENSG00000151923
COSMIC: TIAL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151923ENST00000369086A6NKZ9
ENSG00000151923ENST00000369093Q01085
ENSG00000151923ENST00000412524E7ETJ9
ENSG00000151923ENST00000436547Q01085
ENSG00000151923ENST00000479729A0A087WX93
ENSG00000151923ENST00000497671E7ETC0

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR2REACTOMER-HSA-5654738
FGFR2 alternative splicingREACTOMER-HSA-6803529

References

Pubmed IDYearTitleCitations
210489812010iCLIP predicts the dual splicing effects of TIA-RNA interactions.117
165818012006Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR.94
174860992007Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation.88
165379142006Translational repression by RNA-binding protein TIAR.68
152804672004Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs.53
184568622008A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation.48
211892872011TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.47
176820652007Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR.46
155149712005IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR.41
129173212003U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA.34

Citation

Dessen P

TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43936/tial1