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TICRR (TOPBP1 interacting checkpoint and replication regulator)

Identity

Alias_namesC15orf42
chromosome 15 open reading frame 42
Alias_symbol (synonym)MGC45866
FLJ41618
Treslin
SLD3
Other alias
HGNC (Hugo) TICRR
LocusID (NCBI) 90381
Atlas_Id 51393
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 89575587 and ends at 89628022 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DPP8 (15q22.31) / TICRR (15q26.1)TICRR (15q26.1) / ATXN7L1 (7q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(7;15)(q22;q26) TICRR/ATXN7L1
t(15;15)(q22;q26) DPP8/TICRR

External links

Nomenclature
HGNC (Hugo)TICRR   28704
Cards
Entrez_Gene (NCBI)TICRR  90381  TOPBP1 interacting checkpoint and replication regulator
AliasesC15orf42; SLD3; Treslin
GeneCards (Weizmann)TICRR
Ensembl hg19 (Hinxton)ENSG00000140534 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140534 [Gene_View]  ENSG00000140534 [Sequence]  chr15:89575587-89628022 [Contig_View]  TICRR [Vega]
ICGC DataPortalENSG00000140534
TCGA cBioPortalTICRR
AceView (NCBI)TICRR
Genatlas (Paris)TICRR
WikiGenes90381
SOURCE (Princeton)TICRR
Genetics Home Reference (NIH)TICRR
Genomic and cartography
GoldenPath hg38 (UCSC)TICRR  -     chr15:89575587-89628022 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TICRR  -     15q26.1   [Description]    (hg19-Feb_2009)
GoldenPathTICRR - 15q26.1 [CytoView hg19]  TICRR - 15q26.1 [CytoView hg38]
ImmunoBaseENSG00000140534
Mapping of homologs : NCBITICRR [Mapview hg19]  TICRR [Mapview hg38]
OMIM613298   
Gene and transcription
Genbank (Entrez)AK074727 AK123612 AK315750 AW627706 BC002881
RefSeq transcript (Entrez)NM_001308025 NM_152259
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TICRR
Cluster EST : UnigeneHs.441708 [ NCBI ]
CGAP (NCI)Hs.441708
Alternative Splicing GalleryENSG00000140534
Gene ExpressionTICRR [ NCBI-GEO ]   TICRR [ EBI - ARRAY_EXPRESS ]   TICRR [ SEEK ]   TICRR [ MEM ]
Gene Expression Viewer (FireBrowse)TICRR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)90381
GTEX Portal (Tissue expression)TICRR
Human Protein AtlasENSG00000140534-TICRR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z2Z1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z2Z1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z2Z1
Splice isoforms : SwissVarQ7Z2Z1
PhosPhoSitePlusQ7Z2Z1
Domains : Interpro (EBI)Treslin    Treslin_N   
Domain families : Pfam (Sanger)Treslin_N (PF15292)   
Domain families : Pfam (NCBI)pfam15292   
Conserved Domain (NCBI)TICRR
DMDM Disease mutations90381
Blocks (Seattle)TICRR
SuperfamilyQ7Z2Z1
Human Protein Atlas [tissue]ENSG00000140534-TICRR [tissue]
Peptide AtlasQ7Z2Z1
HPRD11357
IPIIPI00853221   IPI00413144   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z2Z1
IntAct (EBI)Q7Z2Z1
FunCoupENSG00000140534
BioGRIDTICRR
STRING (EMBL)TICRR
ZODIACTICRR
Ontologies - Pathways
QuickGOQ7Z2Z1
Ontology : AmiGOformation of translation preinitiation complex  chromatin binding  protein binding  nucleus  nucleoplasm  DNA replication  DNA repair  mitotic cell cycle checkpoint  response to ionizing radiation  regulation of DNA-dependent DNA replication initiation  mitotic DNA replication checkpoint  
Ontology : EGO-EBIformation of translation preinitiation complex  chromatin binding  protein binding  nucleus  nucleoplasm  DNA replication  DNA repair  mitotic cell cycle checkpoint  response to ionizing radiation  regulation of DNA-dependent DNA replication initiation  mitotic DNA replication checkpoint  
NDEx NetworkTICRR
Atlas of Cancer Signalling NetworkTICRR
Wikipedia pathwaysTICRR
Orthology - Evolution
OrthoDB90381
GeneTree (enSembl)ENSG00000140534
Phylogenetic Trees/Animal Genes : TreeFamTICRR
HOGENOMQ7Z2Z1
Homologs : HomoloGeneTICRR
Homology/Alignments : Family Browser (UCSC)TICRR
Gene fusions - Rearrangements
Fusion : MitelmanDPP8/TICRR [15q22.31/15q26.1]  [t(15;15)(q22;q26)]  
Fusion : MitelmanTICRR/ATXN7L1 [15q26.1/7q22.3]  [t(7;15)(q22;q26)]  
Fusion : QuiverTICRR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTICRR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TICRR
dbVarTICRR
ClinVarTICRR
1000_GenomesTICRR 
Exome Variant ServerTICRR
ExAC (Exome Aggregation Consortium)ENSG00000140534
GNOMAD BrowserENSG00000140534
Varsome BrowserTICRR
Genetic variants : HAPMAP90381
Genomic Variants (DGV)TICRR [DGVbeta]
DECIPHERTICRR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTICRR 
Mutations
ICGC Data PortalTICRR 
TCGA Data PortalTICRR 
Broad Tumor PortalTICRR
OASIS PortalTICRR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTICRR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTICRR
Mutations and Diseases : HGMDTICRR
BioMutasearch TICRR
DgiDB (Drug Gene Interaction Database)TICRR
DoCM (Curated mutations)TICRR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TICRR (select a term)
intoGenTICRR
Cancer3DTICRR(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613298   
Orphanet
DisGeNETTICRR
MedgenTICRR
Genetic Testing Registry TICRR
NextProtQ7Z2Z1 [Medical]
TSGene90381
GENETestsTICRR
Target ValidationTICRR
Huge Navigator TICRR [HugePedia]
snp3D : Map Gene to Disease90381
BioCentury BCIQTICRR
ClinGenTICRR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD90381
Chemical/Pharm GKB GenePA142672278
Clinical trialTICRR
Miscellaneous
canSAR (ICR)TICRR (select the gene name)
DataMed IndexTICRR
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTICRR
EVEXTICRR
GoPubMedTICRR
iHOPTICRR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:11:43 CET 2019
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