TIGIT (T cell immunoreceptor with Ig and ITIM domains)

2010-01-01 Affiliation

Identity

HGNC

TIGIT

LOCATION

3q13.31

LOCUSID

201633

ALIAS

VSIG9,VSTM3,WUCAM

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 201633
MIM: 612859
HGNC: 26838
Ensembl: ENSG00000181847

Variants:

dbSNP: 201633
ClinVar: 201633
TCGA: ENSG00000181847
COSMIC: TIGIT

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000181847	ENST00000383671	Q495A1
ENSG00000181847	ENST00000461158	C9J0B0
ENSG00000181847	ENST00000481065	A0A0C4DGA4
ENSG00000181847	ENST00000484319	C9JZW6
ENSG00000181847	ENST00000486257	Q495A1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Cell adhesion molecules (CAMs)	KEGG	hsa04514

References

Pubmed ID	Year	Title	Citations
19011627	2009	The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.	231
19815499	2009	The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity.	179
25465800	2014	The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.	179
25680274	2015	Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack.	166
25866972	2015	TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients.	141
22427644	2012	The TIGIT/CD226 axis regulates human T cell function.	84
26741490	2016	TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.	83
21416464	2011	Vstm3 is a member of the CD28 family and an important modulator of T-cell function.	72
19197944	2009	A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC.	52
23154388	2013	Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells.	48

Citation

Dessen P

TIGIT (T cell immunoreceptor with Ig and ITIM domains)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51271/tigit