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TIGIT (T cell immunoreceptor with Ig and ITIM domains)

Identity

Alias_namesVSIG9
VSTM3
VSIG9, VSTM3
Alias_symbol (synonym)FLJ39873
DKFZp667A205
Other aliasWUCAM
HGNC (Hugo) TIGIT
LocusID (NCBI) 201633
Atlas_Id 51271
Location 3q13.31  [Link to chromosome band 3q13]
Location_base_pair Starts at 114293986 and ends at 114310288 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TIGIT   26838
Cards
Entrez_Gene (NCBI)TIGIT  201633  T cell immunoreceptor with Ig and ITIM domains
AliasesVSIG9; VSTM3; WUCAM
GeneCards (Weizmann)TIGIT
Ensembl hg19 (Hinxton)ENSG00000181847 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181847 [Gene_View]  ENSG00000181847 [Sequence]  chr3:114293986-114310288 [Contig_View]  TIGIT [Vega]
ICGC DataPortalENSG00000181847
TCGA cBioPortalTIGIT
AceView (NCBI)TIGIT
Genatlas (Paris)TIGIT
WikiGenes201633
SOURCE (Princeton)TIGIT
Genetics Home Reference (NIH)TIGIT
Genomic and cartography
GoldenPath hg38 (UCSC)TIGIT  -     chr3:114293986-114310288 +  3q13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIGIT  -     3q13.31   [Description]    (hg19-Feb_2009)
GoldenPathTIGIT - 3q13.31 [CytoView hg19]  TIGIT - 3q13.31 [CytoView hg38]
ImmunoBaseENSG00000181847
Mapping of homologs : NCBITIGIT [Mapview hg19]  TIGIT [Mapview hg38]
OMIM612859   
Gene and transcription
Genbank (Entrez)AK097192 AL833175 BC101288 BC101289 BC101290
RefSeq transcript (Entrez)NM_173799
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TIGIT
Alternative Splicing GalleryENSG00000181847
Gene ExpressionTIGIT [ NCBI-GEO ]   TIGIT [ EBI - ARRAY_EXPRESS ]   TIGIT [ SEEK ]   TIGIT [ MEM ]
Gene Expression Viewer (FireBrowse)TIGIT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)201633
GTEX Portal (Tissue expression)TIGIT
Human Protein AtlasENSG00000181847-TIGIT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ495A1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ495A1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ495A1
Splice isoforms : SwissVarQ495A1
PhosPhoSitePlusQ495A1
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set    TIGIT   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)TIGIT
DMDM Disease mutations201633
Blocks (Seattle)TIGIT
PDB (RSDB)3Q0H    3RQ3    3UCR    3UDW    5V52   
PDB Europe3Q0H    3RQ3    3UCR    3UDW    5V52   
PDB (PDBSum)3Q0H    3RQ3    3UCR    3UDW    5V52   
PDB (IMB)3Q0H    3RQ3    3UCR    3UDW    5V52   
Structural Biology KnowledgeBase3Q0H    3RQ3    3UCR    3UDW    5V52   
SCOP (Structural Classification of Proteins)3Q0H    3RQ3    3UCR    3UDW    5V52   
CATH (Classification of proteins structures)3Q0H    3RQ3    3UCR    3UDW    5V52   
SuperfamilyQ495A1
Human Protein Atlas [tissue]ENSG00000181847-TIGIT [tissue]
Peptide AtlasQ495A1
HPRD08804
IPIIPI00174439   IPI00789390   IPI00945834   IPI00945475   
Protein Interaction databases
DIP (DOE-UCLA)Q495A1
IntAct (EBI)Q495A1
FunCoupENSG00000181847
BioGRIDTIGIT
STRING (EMBL)TIGIT
ZODIACTIGIT
Ontologies - Pathways
QuickGOQ495A1
Ontology : AmiGOsignaling receptor binding  signaling receptor binding  protein binding  plasma membrane  cell surface  cell surface  integral component of membrane  negative regulation of interleukin-12 production  negative regulation of interleukin-12 production  positive regulation of interleukin-10 production  positive regulation of interleukin-10 production  identical protein binding  negative regulation of T cell activation  negative regulation of T cell activation  negative regulation of T cell activation  
Ontology : EGO-EBIsignaling receptor binding  signaling receptor binding  protein binding  plasma membrane  cell surface  cell surface  integral component of membrane  negative regulation of interleukin-12 production  negative regulation of interleukin-12 production  positive regulation of interleukin-10 production  positive regulation of interleukin-10 production  identical protein binding  negative regulation of T cell activation  negative regulation of T cell activation  negative regulation of T cell activation  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkTIGIT
Atlas of Cancer Signalling NetworkTIGIT
Wikipedia pathwaysTIGIT
Orthology - Evolution
OrthoDB201633
GeneTree (enSembl)ENSG00000181847
Phylogenetic Trees/Animal Genes : TreeFamTIGIT
HOGENOMQ495A1
Homologs : HomoloGeneTIGIT
Homology/Alignments : Family Browser (UCSC)TIGIT
Gene fusions - Rearrangements
Fusion : QuiverTIGIT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIGIT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIGIT
dbVarTIGIT
ClinVarTIGIT
1000_GenomesTIGIT 
Exome Variant ServerTIGIT
ExAC (Exome Aggregation Consortium)ENSG00000181847
GNOMAD BrowserENSG00000181847
Varsome BrowserTIGIT
Genetic variants : HAPMAP201633
Genomic Variants (DGV)TIGIT [DGVbeta]
DECIPHERTIGIT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIGIT 
Mutations
ICGC Data PortalTIGIT 
TCGA Data PortalTIGIT 
Broad Tumor PortalTIGIT
OASIS PortalTIGIT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIGIT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTIGIT
Mutations and Diseases : HGMDTIGIT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TIGIT
DgiDB (Drug Gene Interaction Database)TIGIT
DoCM (Curated mutations)TIGIT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TIGIT (select a term)
intoGenTIGIT
Cancer3DTIGIT(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612859   
Orphanet
DisGeNETTIGIT
MedgenTIGIT
Genetic Testing Registry TIGIT
NextProtQ495A1 [Medical]
TSGene201633
GENETestsTIGIT
Target ValidationTIGIT
Huge Navigator TIGIT [HugePedia]
snp3D : Map Gene to Disease201633
BioCentury BCIQTIGIT
ClinGenTIGIT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD201633
Chemical/Pharm GKB GenePA164726482
Clinical trialTIGIT
Miscellaneous
canSAR (ICR)TIGIT (select the gene name)
HarmonizomeTIGIT
DataMed IndexTIGIT
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTIGIT
EVEXTIGIT
GoPubMedTIGIT
iHOPTIGIT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Mar 11 19:35:20 CET 2020
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