TIMM23 (translocase of inner mitochondrial membrane 23)

2003-06-01  

Identity

HGNC
TIMM23
LOCATION
10q11.22
LOCUSID
100287932
ALIAS
TIM23
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 100287932
MIM: 605034
HGNC: 17312
Ensembl: ENSG00000265354

Variants:

dbSNP: 100287932
ClinVar: 100287932
TCGA: ENSG00000265354
COSMIC: TIMM23

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000265354ENST00000580018O14925

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Mitochondrial protein importREACTOMER-HSA-1268020

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
232601402012MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation.49
232638642013Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria.17
294139002018Expression of the human TIMM23 and TIMM23B genes is regulated by the GABP transcription factor.2
313460862019Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23.2
223067442012The structural characteristics of human preprotein translocase of the inner mitochondrial membrane Tim23: implications for its physiological activities.0
238114012013Interaction of presequence peptides with human translocase of inner membrane of mitochondria Tim23.0
246369902014Unraveling the intricate organization of mammalian mitochondrial presequence translocases: existence of multiple translocases for maintenance of mitochondrial function.0
255192392014Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders.0
271782152016Interaction of divalent metal ions with human translocase of inner membrane of mitochondria Tim23.0

Citation

Dessen P

TIMM23 (translocase of inner mitochondrial membrane 23)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42566/timm23