Identity
HGNC
LOCATION
22q12.3
LOCUSID
ALIAS
HSMRK222,K222,K222TA2,SFD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7078
MIM: 188826
HGNC: 11822
Ensembl: ENSG00000100234
Variants:
dbSNP: 7078
ClinVar: 7078
TCGA: ENSG00000100234
COSMIC: TIMP3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000100234 | ENST00000266085 | P35625 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA30086 | KDR | Gene | Pathway | associated | 20124951 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38345407 | 2024 | Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2-dependent TIMP3 m6A modification. | 0 |
| 38369214 | 2024 | TIMP3/Wnt axis regulates gliosis of Müller glia. | 0 |
| 38601018 | 2024 | Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy. | 0 |
| 38612555 | 2024 | Disease-Causing TIMP3 Variants and Deep Phenotyping of Two Czech Families with Sorsby Fundus Dystrophy Associated with Novel p.(Tyr152Cys) Mutation. | 0 |
| 38798256 | 2024 | Demethylation of TIMP2 and TIMP3 Inhibits Cell Proliferation, Migration, and Invasion in Pituitary Adenomas. | 0 |
| 38345407 | 2024 | Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2-dependent TIMP3 m6A modification. | 0 |
| 38369214 | 2024 | TIMP3/Wnt axis regulates gliosis of Müller glia. | 0 |
| 38601018 | 2024 | Review: Mechanisms of TIMP-3 accumulation and pathogenesis in Sorsby fundus dystrophy. | 0 |
| 38612555 | 2024 | Disease-Causing TIMP3 Variants and Deep Phenotyping of Two Czech Families with Sorsby Fundus Dystrophy Associated with Novel p.(Tyr152Cys) Mutation. | 0 |
| 38798256 | 2024 | Demethylation of TIMP2 and TIMP3 Inhibits Cell Proliferation, Migration, and Invasion in Pituitary Adenomas. | 0 |
| 36093887 | 2023 | Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis. | 1 |
| 36333976 | 2023 | Circulating levels of tissue inhibitor of metalloproteinase 3, a protein with inhibitory effects on angiogenesis, are increased in pre-eclampsia. | 2 |
| 37414199 | 2023 | Targeting of HBP1/TIMP3 axis as a novel strategy against breast cancer. | 2 |
| 37844423 | 2023 | Loss of TIMP3, but not TIMP4, exacerbates thoracic and abdominal aortic aneurysm. | 0 |
| 36093887 | 2023 | Differential gene expression of ADAMTS-1, ADAMTS-9 and TIMP-3 in periodontitis. | 1 |
Citation
Dessen P
TIMP3 (TIMP metallopeptidase inhibitor 3)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42573/timp3
