Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TKT (transketolase)

Identity

Other aliasHEL-S-48
HEL107
SDDHD
TK
TKT1
HGNC (Hugo) TKT
LocusID (NCBI) 7086
Atlas_Id 53265
Location 3p21.1  [Link to chromosome band 3p21]
Location_base_pair Starts at 53225636 and ends at 53256114 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AD_1 () / TKT (3p21.1)CDC37 (19p13.2) / TKT (3p21.1)PBRM1 (3p21.1) / TKT (3p21.1)
RPL11 (1p36.11) / TKT (3p21.1)TKT (3p21.1) / C3orf67 (3p14.2)TKT (3p21.1) / CPXM2 (10q26.13)
TKT (3p21.1) / TKT (3p21.1)TKT (3p21.1) / YLPM1 (14q24.3)UBE2J2 (1p36.33) / TKT (3p21.1)
PBRM1 3p21.1 / TKT 3p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  PBRM1/TKT (3p21)

External links

Nomenclature
HGNC (Hugo)TKT   11834
Cards
Entrez_Gene (NCBI)TKT  7086  transketolase
AliasesHEL-S-48; HEL107; SDDHD; TK; 
TKT1
GeneCards (Weizmann)TKT
Ensembl hg19 (Hinxton)ENSG00000163931 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163931 [Gene_View]  ENSG00000163931 [Sequence]  chr3:53225636-53256114 [Contig_View]  TKT [Vega]
ICGC DataPortalENSG00000163931
TCGA cBioPortalTKT
AceView (NCBI)TKT
Genatlas (Paris)TKT
WikiGenes7086
SOURCE (Princeton)TKT
Genetics Home Reference (NIH)TKT
Genomic and cartography
GoldenPath hg38 (UCSC)TKT  -     chr3:53225636-53256114 -  3p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TKT  -     3p21.1   [Description]    (hg19-Feb_2009)
GoldenPathTKT - 3p21.1 [CytoView hg19]  TKT - 3p21.1 [CytoView hg38]
ImmunoBaseENSG00000163931
Mapping of homologs : NCBITKT [Mapview hg19]  TKT [Mapview hg38]
OMIM606781   617044   
Gene and transcription
Genbank (Entrez)AK057092 AK092084 AK093667 AK223614 AK289454
RefSeq transcript (Entrez)NM_001064 NM_001135055 NM_001135056 NM_001258028
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TKT
Cluster EST : UnigeneHs.89643 [ NCBI ]
CGAP (NCI)Hs.89643
Alternative Splicing GalleryENSG00000163931
Gene ExpressionTKT [ NCBI-GEO ]   TKT [ EBI - ARRAY_EXPRESS ]   TKT [ SEEK ]   TKT [ MEM ]
Gene Expression Viewer (FireBrowse)TKT [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7086
GTEX Portal (Tissue expression)TKT
Human Protein AtlasENSG00000163931-TKT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29401   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29401  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29401
Splice isoforms : SwissVarP29401
Catalytic activity : Enzyme2.2.1.1 [ Enzyme-Expasy ]   2.2.1.12.2.1.1 [ IntEnz-EBI ]   2.2.1.1 [ BRENDA ]   2.2.1.1 [ KEGG ]   
PhosPhoSitePlusP29401
Domaine pattern : Prosite (Expaxy)TRANSKETOLASE_1 (PS00801)    TRANSKETOLASE_2 (PS00802)   
Domains : Interpro (EBI)THDP-binding    Transketo_C/PFOR_II    Transketolase-like_Pyr-bd    Transketolase_BS    Transketolase_C    Transketolase_N   
Domain families : Pfam (Sanger)Transket_pyr (PF02779)    Transketolase_C (PF02780)    Transketolase_N (PF00456)   
Domain families : Pfam (NCBI)pfam02779    pfam02780    pfam00456   
Domain families : Smart (EMBL)Transket_pyr (SM00861)  
Conserved Domain (NCBI)TKT
DMDM Disease mutations7086
Blocks (Seattle)TKT
PDB (RSDB)3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY   
PDB Europe3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY   
PDB (PDBSum)3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY   
PDB (IMB)3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY   
Structural Biology KnowledgeBase3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY   
SCOP (Structural Classification of Proteins)3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY   
CATH (Classification of proteins structures)3MOS    3OOY    4KXU    4KXV    4KXW    4KXX    4KXY   
SuperfamilyP29401
Human Protein Atlas [tissue]ENSG00000163931-TKT [tissue]
Peptide AtlasP29401
HPRD06001
IPIIPI00942979   IPI00940673   IPI00946864   IPI00946973   IPI00643920   IPI00947136   
Protein Interaction databases
DIP (DOE-UCLA)P29401
IntAct (EBI)P29401
FunCoupENSG00000163931
BioGRIDTKT
STRING (EMBL)TKT
ZODIACTKT
Ontologies - Pathways
QuickGOP29401
Ontology : AmiGOtransketolase activity  protein binding  nucleoplasm  peroxisome  cytosol  xylulose biosynthetic process  pentose-phosphate shunt  pentose-phosphate shunt, non-oxidative branch  nuclear body  nuclear speck  vesicle  regulation of growth  protein homodimerization activity  glyceraldehyde-3-phosphate biosynthetic process  metal ion binding  cofactor binding  extracellular exosome  
Ontology : EGO-EBItransketolase activity  protein binding  nucleoplasm  peroxisome  cytosol  xylulose biosynthetic process  pentose-phosphate shunt  pentose-phosphate shunt, non-oxidative branch  nuclear body  nuclear speck  vesicle  regulation of growth  protein homodimerization activity  glyceraldehyde-3-phosphate biosynthetic process  metal ion binding  cofactor binding  extracellular exosome  
Pathways : KEGGPentose phosphate pathway   
NDEx NetworkTKT
Atlas of Cancer Signalling NetworkTKT
Wikipedia pathwaysTKT
Orthology - Evolution
OrthoDB7086
GeneTree (enSembl)ENSG00000163931
Phylogenetic Trees/Animal Genes : TreeFamTKT
HOGENOMP29401
Homologs : HomoloGeneTKT
Homology/Alignments : Family Browser (UCSC)TKT
Gene fusions - Rearrangements
Fusion : MitelmanPBRM1/TKT [3p21.1/3p21.1]  [t(3;3)(p21;p21)]  
Fusion PortalPBRM1 3p21.1 TKT 3p21.1 BRCA
Fusion Cancer (Beijing)AD_1 [TKT]  -  3p21.1 [FUSC000402]
Fusion : QuiverTKT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTKT [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TKT
dbVarTKT
ClinVarTKT
1000_GenomesTKT 
Exome Variant ServerTKT
ExAC (Exome Aggregation Consortium)ENSG00000163931
GNOMAD BrowserENSG00000163931
Varsome BrowserTKT
Genetic variants : HAPMAP7086
Genomic Variants (DGV)TKT [DGVbeta]
DECIPHERTKT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTKT 
Mutations
ICGC Data PortalTKT 
TCGA Data PortalTKT 
Broad Tumor PortalTKT
OASIS PortalTKT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTKT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTKT
Mutations and Diseases : HGMDTKT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TKT
DgiDB (Drug Gene Interaction Database)TKT
DoCM (Curated mutations)TKT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TKT (select a term)
intoGenTKT
Cancer3DTKT(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606781    617044   
Orphanet
DisGeNETTKT
MedgenTKT
Genetic Testing Registry TKT
NextProtP29401 [Medical]
TSGene7086
GENETestsTKT
Target ValidationTKT
Huge Navigator TKT [HugePedia]
snp3D : Map Gene to Disease7086
BioCentury BCIQTKT
ClinGenTKT
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7086
Chemical/Pharm GKB GenePA36537
Clinical trialTKT
Miscellaneous
canSAR (ICR)TKT (select the gene name)
DataMed IndexTKT
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTKT
EVEXTKT
GoPubMedTKT
iHOPTKT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:11:49 CET 2019
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.