TKTL1 (transketolase like 1)

2007-02-01  

Identity

HGNC
TKTL1
LOCATION
Xq28
LOCUSID
8277
ALIAS
TKR,TKT2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8277
MIM: 300044
HGNC: 11835
Ensembl: ENSG00000007350

Variants:

dbSNP: 8277
ClinVar: 8277
TCGA: ENSG00000007350
COSMIC: TKTL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007350ENST00000369912P51854
ENSG00000007350ENST00000369915P51854
ENSG00000007350ENST00000426203H0Y808
ENSG00000007350ENST00000426989A2ID95
ENSG00000007350ENST00000439635F8WF97

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pentose phosphate pathwayKEGGko00030
Pentose phosphate pathwayKEGGhsa00030
Metabolic pathwaysKEGGhsa01100
Pentose phosphate pathway (Pentose phosphate cycle)KEGGhsa_M00004
Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5PKEGGhsa_M00007
Pentose phosphate pathway (Pentose phosphate cycle)KEGGM00004
Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5PKEGGM00007
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
164651942006Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted.70
201036832010TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization.49
159917992005Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer.46
190656562009Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells.39
183021542008Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer.36
203850082010Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1.29
173210412007Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells.25
173210412007Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells.25
219804272011Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation.23
220277412011Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression.22

Citation

Dessen P

TKTL1 (transketolase like 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46003/tktl1