TLE4 (TLE family member 4, transcriptional corepressor)

2016-12-01  

Identity

HGNC
LOCATION
9q21.31
LOCUSID
ALIAS
BCE-1,BCE1,E(spI),E(spl),ESG,ESG4,GRG4,Grg-4
FUSION GENES

Other Information

Locus ID:

NCBI: 7091
MIM: 605132
HGNC: 11840
Ensembl: ENSG00000106829

Variants:

dbSNP: 7091
ClinVar: 7091
TCGA: ENSG00000106829
COSMIC: TLE4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106829ENST00000265284Q04727
ENSG00000106829ENST00000376537Q04727
ENSG00000106829ENST00000376544Q04727
ENSG00000106829ENST00000376552Q04727
ENSG00000106829ENST00000414465Q5JSZ2
ENSG00000106829ENST00000417836H0Y5S0
ENSG00000106829ENST00000425506Q5JSY8
ENSG00000106829ENST00000428713Q5JSY7
ENSG00000106829ENST00000435650Q5JSZ1
ENSG00000106829ENST00000461758A0A0A0MT79
ENSG00000106829ENST00000462803E7EQH3
ENSG00000106829ENST00000467142H7C4W5
ENSG00000106829ENST00000470872F8WAY5
ENSG00000106829ENST00000490347H7C4P7
ENSG00000106829ENST00000496114H7C4E4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402

References

Pubmed IDYearTitleCitations
197142052009Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.77
208898532011Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.65
208161952010Analyses of shared genetic factors between asthma and obesity in children.43
182587962008Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.35
221692762012Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.29
229274672012SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest.21
198936082009The germ cell nuclear proteins hnRNP G-T and RBMY activate a testis-specific exon.16
170604512007Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors.14
267012082016TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway.12
256310482015The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.8

Citation

Dessen P

TLE4 (TLE family member 4, transcriptional corepressor)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56639/tle4