TLE5 (TLE family member 5, transcriptional modulator)

2012-12-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
AES,AES-1,AES-2,ESP1,GRG,GRG5,Grg-5
FUSION GENES

Other Information

Locus ID:

NCBI: 166
MIM: 600188
HGNC: 307
Ensembl: ENSG00000104964

Variants:

dbSNP: 166
ClinVar: 166
TCGA: ENSG00000104964
COSMIC: TLE5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104964ENST00000221561Q08117
ENSG00000104964ENST00000327141Q08117
ENSG00000104964ENST00000585557K7ELQ8
ENSG00000104964ENST00000586742K7ELE3
ENSG00000104964ENST00000586839K7EQH5

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Degradation of beta-catenin by the destruction complexREACTOMER-HSA-195253
Repression of WNT target genesREACTOMER-HSA-4641265

References

Pubmed IDYearTitleCitations
150063562004A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors.54
184389192008Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction.16
212454882011AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.12
206763682010Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD.9
235465942013Suppression of RND3 activity by AES downregulation promotes cancer cell proliferation and invasion.8
219374512011Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.6
281783912017Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer.5
201633602010Structural and functional analysis of amino-terminal enhancer of split in androgen-receptor-driven transcription.4
238408762013GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos.4
275611712016Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.4

Citation

Dessen P

TLE5 (TLE family member 5, transcriptional modulator)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53080/tle5