TLK1 (tousled like kinase 1)

2006-10-01  

Identity

HGNC
TLK1
LOCATION
2q31.1
LOCUSID
9874
ALIAS
PKU-beta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9874
MIM: 608438
HGNC: 11841
Ensembl: ENSG00000198586

Variants:

dbSNP: 9874
ClinVar: 9874
TCGA: ENSG00000198586
COSMIC: TLK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198586ENST00000359766F8W7X8
ENSG00000198586ENST00000409443B3KRP1
ENSG00000198586ENST00000431350Q9UKI8
ENSG00000198586ENST00000453628C9JWT6

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
129550712003Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.29
245988212014Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication.24
161569022005The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks.19
200167862009Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.16
243768972013Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit.16
170547862006TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1.15
210487942011Adenoviral delivery of Tousled kinase for the protection of salivary glands against ionizing radiation damage.15
188381282008PKU-beta/TLK1 regulates myosin II activities, and is required for accurate equaled chromosome segregation.10
216479342011The expression of Tousled kinases in CaP cell lines and its relation to radiation response and DSB repair.10
268554192016Tousled kinase activator, gallic acid, promotes homologous recombinational repair and suppresses radiation cytotoxicity in salivary gland cells.8

Citation

Dessen P

TLK1 (tousled like kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43529/tlk1