Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7098
MIM: 603029
HGNC: 11849
Ensembl: ENSG00000164342
Variants:
dbSNP: 7098
ClinVar: 7098
TCGA: ENSG00000164342
COSMIC: TLR3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000164342 | ENST00000296795 | O15455 |
| ENSG00000164342 | ENST00000504367 | O15455 |
| ENSG00000164342 | ENST00000513189 | D6RA51 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712887 | Measles vaccines | Chemical | ClinicalAnnotation | associated | PD | ||
| PA443450 | Asthma | Disease | ClinicalAnnotation | associated | PD | ||
| PA448497 | aspirin | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38049523 | 2024 | Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment. | 0 |
| 38316991 | 2024 | Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer. | 1 |
| 38551071 | 2024 | UPK3A(+) umbrella cell damage mediated by TLR3-NR2F6 triggers programmed destruction of urothelium in Hunner-type interstitial cystitis/painful bladder syndrome. | 0 |
| 38868969 | 2024 | Strong association of TLR2 and TLR3 polymorphisms with keratoacanthoma and common warts: a case-control study. | 0 |
| 38907187 | 2024 | Genetic variation of TLR3 gene is associated with the outcome of hepatitis b infection in mauritanian patients: case control study. | 0 |
| 38049523 | 2024 | Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment. | 0 |
| 38316991 | 2024 | Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer. | 1 |
| 38551071 | 2024 | UPK3A(+) umbrella cell damage mediated by TLR3-NR2F6 triggers programmed destruction of urothelium in Hunner-type interstitial cystitis/painful bladder syndrome. | 0 |
| 38868969 | 2024 | Strong association of TLR2 and TLR3 polymorphisms with keratoacanthoma and common warts: a case-control study. | 0 |
| 38907187 | 2024 | Genetic variation of TLR3 gene is associated with the outcome of hepatitis b infection in mauritanian patients: case control study. | 0 |
| 36271773 | 2023 | Toll-like receptors 3, 7, 8, and 9 in gastric cancer. | 0 |
| 36478230 | 2023 | Do CCR5 (CCR5Δ32) and TLR3 (RS5743313) gene polymorphisms prevent chronic hepatitis B infection? | 0 |
| 36631495 | 2023 | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. | 7 |
| 37013819 | 2023 | Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification. | 5 |
| 37020259 | 2023 | Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. | 26 |
Citation
Dessen P
TLR3 (toll like receptor 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43628/tlr3
