TLR5 (toll like receptor 5)

2003-06-01  

Identity

HGNC
LOCATION
1q41
LOCUSID
ALIAS
MELIOS,SLE1,SLEB1,TIL3
FUSION GENES

Other Information

Locus ID:

NCBI: 7100
MIM: 603031
HGNC: 11851
Ensembl: ENSG00000187554

Variants:

dbSNP: 7100
ClinVar: 7100
TCGA: ENSG00000187554
COSMIC: TLR5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187554ENST00000407096B1AZ06
ENSG00000187554ENST00000540964O60602
ENSG00000187554ENST00000642603A0A2R8Y7Z4
ENSG00000187554ENST00000645434A0A2R8Y4Q2

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Pathogenic Escherichia coli infectionKEGGko05130
Toll-like receptor signaling pathwayKEGGhsa04620
Pathogenic Escherichia coli infectionKEGGhsa05130
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
DiseaseREACTOMER-HSA-1643685
Diseases of Immune SystemREACTOMER-HSA-5260271
Diseases associated with the TLR signaling cascadeREACTOMER-HSA-5602358
IRAK4 deficiency (TLR5)REACTOMER-HSA-5603037
MyD88 deficiency (TLR5)REACTOMER-HSA-5602680
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalVariantAnnotationassociatedPD28139755
PA166048654ustekinumabChemicalClinicalAnnotationassociatedPD28696418
PA443815Crohn DiseaseDiseaseVariantAnnotationassociatedPD28139755
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD28696418

References

Pubmed IDYearTitleCitations
159562022005Evasion of Toll-like receptor 5 by flagellated bacteria.188
201009332010Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.163
127343642003The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.126
163395422005Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells.105
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
196207712009Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity.92
146078142004Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191204902009Systems biology of innate immunity.74
255333362015Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.72

Citation

Dessen P

TLR5 (toll like receptor 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42581/tlr5