TLR6 (toll like receptor 6)

2007-02-01 Affiliation

Identity

HGNC

TLR6

LOCATION

4p14

LOCUSID

10333

ALIAS

CD286

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10333
MIM: 605403
HGNC: 16711
Ensembl: ENSG00000174130

Variants:

dbSNP: 10333
ClinVar: 10333
TCGA: ENSG00000174130
COSMIC: TLR6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000174130	ENST00000381950	Q9Y2C9
ENSG00000174130	ENST00000436693	Q9Y2C9
ENSG00000174130	ENST00000508254	D6RAV7
ENSG00000174130	ENST00000514655	D6R979
ENSG00000174130	ENST00000610323	Q9Y2C9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Toll-like receptor signaling pathway	KEGG	ko04620
Toll-like receptor signaling pathway	KEGG	hsa04620
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Disease	REACTOME	R-HSA-1643685
Diseases of Immune System	REACTOME	R-HSA-5260271
Diseases associated with the TLR signaling cascade	REACTOME	R-HSA-5602358
IRAK4 deficiency (TLR2/4)	REACTOME	R-HSA-5603041
MyD88 deficiency (TLR2/4)	REACTOME	R-HSA-5602498
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing-Cross presentation	REACTOME	R-HSA-1236975
ER-Phagosome pathway	REACTOME	R-HSA-1236974
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Regulation of TLR by endogenous ligand	REACTOME	R-HSA-5686938

References

Pubmed ID	Year	Title	Citations
20037584	2010	CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.	466
20100933	2010	Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.	163
16880211	2006	Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting.	150
19543380	2009	Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome.	141
14966134	2004	Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.	132
18056480	2008	Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.	105
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
16374251	2006	Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.	82
20348427	2010	Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.	79
18091991	2007	Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.	75

Citation

Dessen P

TLR6 (toll like receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43954/tlr6