Identity
HGNC
LOCATION
Xp22.2
LOCUSID
ALIAS
IMD74,TLR7-like
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51284
MIM: 300365
HGNC: 15631
Ensembl: ENSG00000196664
Variants:
dbSNP: 51284
ClinVar: 51284
TCGA: ENSG00000196664
COSMIC: TLR7
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000196664 | ENST00000380659 | Q9NYK1 |
| ENSG00000196664 | ENST00000380659 | B2R9N9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443613 | Carcinoma, Basal Cell | Disease | ClinicalAnnotation | associated | PD | 26556041 | |
| PA449972 | imiquimod | Chemical | ClinicalAnnotation | associated | PD | 26556041 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37341646 | 2024 | Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis. | 1 |
| 38207015 | 2024 | Disrupted degradative sorting of TLR7 is associated with human lupus. | 6 |
| 38296538 | 2024 | Relationship of Toll-Like Receptor 7, 9, and 10 Polymorphisms and the Severity of Coronavirus Disease 2019. | 0 |
| 38324161 | 2024 | Interface Gain-of-Function Mutations in TLR7 Cause Systemic and Neuro-inflammatory Disease. | 1 |
| 38341589 | 2024 | Decreased TLR7 expression was associated with airway eosinophilic inflammation and lung function in asthma: evidence from machine learning approaches and experimental validation. | 0 |
| 38439071 | 2024 | Elevated expression of Toll-like receptor 7 and its correlation with clinical features in patients with primary Sjögren's syndrome. | 0 |
| 38573237 | 2024 | Altered TLR7 Expression-Mediated Immune Modulation Is Supportive of Persistent Replication and Intrauterine Transmission of HBV. | 0 |
| 38683985 | 2024 | The tRNA(Val) half: A strong endogenous Toll-like receptor 7 ligand with a 5'-terminal universal sequence signature. | 0 |
| 37341646 | 2024 | Platelet TLR7 is essential for the formation of platelet-neutrophil complexes and low-density neutrophils in lupus nephritis. | 1 |
| 38207015 | 2024 | Disrupted degradative sorting of TLR7 is associated with human lupus. | 6 |
| 38296538 | 2024 | Relationship of Toll-Like Receptor 7, 9, and 10 Polymorphisms and the Severity of Coronavirus Disease 2019. | 0 |
| 38324161 | 2024 | Interface Gain-of-Function Mutations in TLR7 Cause Systemic and Neuro-inflammatory Disease. | 1 |
| 38341589 | 2024 | Decreased TLR7 expression was associated with airway eosinophilic inflammation and lung function in asthma: evidence from machine learning approaches and experimental validation. | 0 |
| 38439071 | 2024 | Elevated expression of Toll-like receptor 7 and its correlation with clinical features in patients with primary Sjögren's syndrome. | 0 |
| 38573237 | 2024 | Altered TLR7 Expression-Mediated Immune Modulation Is Supportive of Persistent Replication and Intrauterine Transmission of HBV. | 0 |
Citation
Dessen P
TLR7 (toll like receptor 7)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43892/tlr7
