TLR8 (toll like receptor 8)

2007-02-01  

Identity

HGNC
LOCATION
Xp22.2
LOCUSID
ALIAS
CD288

Other Information

Locus ID:

NCBI: 51311
MIM: 300366
HGNC: 15632
Ensembl: ENSG00000101916

Variants:

dbSNP: 51311
ClinVar: 51311
TCGA: ENSG00000101916
COSMIC: TLR8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101916ENST00000218032Q9NR97
ENSG00000101916ENST00000311912Q9NR97

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Trafficking and processing of endosomal TLRREACTOMER-HSA-1679131
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signalingREACTOMER-HSA-975110
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
149762622004Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.971
208323402010Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors.379
161233022005Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function.220
120325572002Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.211
201009332010Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.163
203641512010HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells.119
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
189276252008Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis.88
189276252008Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85

Citation

Dessen P

TLR8 (toll like receptor 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45973/tlr8