TLR9 (toll like receptor 9)

2007-02-01  

Identity

HGNC
LOCATION
3p21.2
LOCUSID
ALIAS
CD289
FUSION GENES

Other Information

Locus ID:

NCBI: 54106
MIM: 605474
HGNC: 15633
Ensembl: ENSG00000239732

Variants:

dbSNP: 54106
ClinVar: 54106
TCGA: ENSG00000239732
COSMIC: TLR9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000239732ENST00000360658Q9NR96

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Toll-like receptor signaling pathwayKEGGhsa04620
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MalariaKEGGko05144
MalariaKEGGhsa05144
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Trafficking and processing of endosomal TLRREACTOMER-HSA-1679131
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signalingREACTOMER-HSA-975110
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
PI3K CascadeREACTOMER-HSA-109704
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD24776844, 28696418
PA443815Crohn DiseaseDiseaseClinicalAnnotationassociatedPD24776844
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD28696418
PA446116Inflammatory Bowel DiseasesDiseaseClinicalAnnotationassociatedPD24776844

References

Pubmed IDYearTitleCitations
147163102004TLR9 signals after translocating from the ER to CpG DNA in the lysosome.375
162304782005Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.280
188068032008Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections.205
125602172003A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells.186
201009332010Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response.163
213986122011Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines.150
195643542009Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.147
232193902012Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.146
153071862004Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner.142
205593882010TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.129

Citation

Dessen P

TLR9 (toll like receptor 9)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46112/tlr9