TLX1 (T cell leukemia homeobox 1)

2003-02-01  

Identity

HGNC
LOCATION
10q24.31
LOCUSID
ALIAS
HOX11,TCL3
FUSION GENES

Other Information

Locus ID:

NCBI: 3195
MIM: 186770
HGNC: 5056
Ensembl: ENSG00000107807

Variants:

dbSNP: 3195
ClinVar: 3195
TCGA: ENSG00000107807
COSMIC: TLX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107807ENST00000370196P31314
ENSG00000107807ENST00000463716G3V1B7
ENSG00000107807ENST00000467928P31314

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

References

Pubmed IDYearTitleCitations
223669492012Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.61
209724332010The TLX1 oncogene drives aneuploidy in T cell transformation.60
225162632012TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRα gene expression.36
181874182008V(D)J recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies.21
158978792005G1/S transcriptional networks modulated by the HOX11/TLX1 oncogene of T-cell acute lymphoblastic leukemia.19
240017732013G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia.16
145041102004Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.15
176094272007Prognostic and oncogenic relevance of TLX1/HOX11 expression level in T-ALLs.14
192506472009Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors.13
172138052007TLX1/HOX11-induced hematopoietic differentiation blockade.12

Citation

Dessen P

TLX1 (T cell leukemia homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/31/tlx1