TM4SF1 (transmembrane 4 L six family member 1)

2003-06-01  

Identity

HGNC
TM4SF1
LOCATION
3q25.1
LOCUSID
4071
ALIAS
H-L6,L6,M3S1,TAAL6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4071
MIM: 191155
HGNC: 11853
Ensembl: ENSG00000169908

Variants:

dbSNP: 4071
ClinVar: 4071
TCGA: ENSG00000169908
COSMIC: TM4SF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169908ENST00000305366P30408
ENSG00000169908ENST00000472441C9J611
ENSG00000169908ENST00000493298F8WBG6
ENSG00000169908ENST00000493348F8WF27

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
242854642014hsa-miR-141 downregulates TM4SF1 to inhibit pancreatic cancer cell invasion and migration.30
128556612003Tumor-associated antigen L6 and the invasion of human lung cancer cells.28
194015442009Four-gene expression ratio test for survival in patients undergoing surgery for mesothelioma.25
269838912016MicroRNA-9 suppresses cell migration and invasion through downregulation of TM4SF1 in colorectal cancer.24
182702652008The tumour-associated antigen L6 (L6-Ag) is recruited to the tetraspanin-enriched microdomains: implication for tumour cell motility.22
216568342011TM4SF1, a novel primary androgen receptor target gene over-expressed in human prostate cancer and involved in cell migration.18
274595142016TM4SF1 Regulates Pancreatic Cancer Migration and Invasion In Vitro and In Vivo.18
216262802011TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration.17
264646502015Role of TM4SF1 in regulating breast cancer cell migration and apoptosis through PI3K/AKT/mTOR pathway.14
283680502017TM4SF1 Promotes Metastasis of Pancreatic Cancer via Regulating the Expression of DDR1.14

Citation

Dessen P

TM4SF1 (transmembrane 4 L six family member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42583/tm4sf1