TM4SF5 (transmembrane 4 L six family member 5)

2003-06-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 9032
MIM: 604657
HGNC: 11857
Ensembl: ENSG00000142484

Variants:

dbSNP: 9032
ClinVar: 9032
TCGA: ENSG00000142484
COSMIC: TM4SF5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142484ENST00000270560O14894

Expression (GTEx)

0
50
100
150

References

Pubmed IDYearTitleCitations
183573442008Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma.37
190367032009Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity.24
222927742012Cross-talk between TGFβ1 and EGFR signalling pathways induces TM4SF5 expression and epithelial-mesenchymal transition.20
230771742012Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells.20
256270852015Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells.16
205065532010Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis.14
221781312012Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition.12
168284712006Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment.11
220149792012JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27(Kip1) phosphorylation.9
250330482014Correlations between transmembrane 4 L6 family member 5 (TM4SF5), CD151, and CD63 in liver fibrotic phenotypes and hepatic migration and invasive capacities.9

Citation

Dessen P

TM4SF5 (transmembrane 4 L six family member 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42586/tm4sf5