TMBIM4 (transmembrane BAX inhibitor motif containing 4)

2008-08-01  

Identity

HGNC
TMBIM4
LOCATION
12q14.3
LOCUSID
51643
ALIAS
CGI-119,GAAP,LFG4,S1R,ZPRO
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51643
MIM: 616874
HGNC: 24257
Ensembl: ENSG00000155957

Variants:

dbSNP: 51643
ClinVar: 51643
TCGA: ENSG00000155957
COSMIC: TMBIM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155957ENST00000286424G3XAA5
ENSG00000155957ENST00000358230Q9HC24
ENSG00000155957ENST00000398033E7EWY5
ENSG00000155957ENST00000534930F5GXT9
ENSG00000155957ENST00000535812F5GXT9
ENSG00000155957ENST00000542724G3V1M2
ENSG00000155957ENST00000544599G3V1R8
ENSG00000155957ENST00000545407F5GXT9
ENSG00000155957ENST00000545504F5H1S4
ENSG00000155957ENST00000556010L7MUG5
ENSG00000155957ENST00000613669A0A087WXH1
ENSG00000155957ENST00000633367Q7Z782

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
173197412007A new inhibitor of apoptosis from vaccinia virus and eukaryotes.41
195534692009Human Golgi antiapoptotic protein modulates intracellular calcium fluxes.26
224184392012Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family.23
257649782015The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.23
239401162013hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2.20
235089502013Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium.10
284690072017Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer.10
184408692008Comparative genomics and function analysis on BI1 family.9
230009032013Host cell Golgi anti-apoptotic protein (GAAP) and growth of Chlamydia pneumoniae.1

Citation

Dessen P

TMBIM4 (transmembrane BAX inhibitor motif containing 4)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50313/tmbim4