Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TMED10 (transmembrane p24 trafficking protein 10)

Identity

Alias_namestransmembrane emp24-like trafficking protein 10 (yeast)
Alias_symbol (synonym)TMP21
P24(DELTA)
p24d1
p24delta1
p23
Other aliasS31I125
S31III125
Tmp-21-I
HGNC (Hugo) TMED10
LocusID (NCBI) 10972
Atlas_Id 56626
Location 14q24.3  [Link to chromosome band 14q24]
Location_base_pair Starts at 75131468 and ends at 75176646 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DISP2 (15q15.1) / TMED10 (14q24.3)IL6 (7p15.3) / TMED10 (14q24.3)LOC100507412 (-) / TMED10 (14q24.3)
TMED10 (14q24.3) / IL6 (7p15.3)TMED10 (14q24.3) / MALAT1 (11q13.1)TMED10 (14q24.3) / PSMD11 (17q11.2)
TMED10 (14q24.3) / THSD4 (15q23)TMED10 (14q24.3) / TTLL5 (14q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  TMED10/TTLL5 (14q24)
t(14;17)(q24;q11) TMED10/PSMD11

External links

Nomenclature
HGNC (Hugo)TMED10   16998
Cards
Entrez_Gene (NCBI)TMED10  10972  transmembrane p24 trafficking protein 10
AliasesP24(DELTA); S31I125; S31III125; TMP21; 
Tmp-21-I; p23; p24d1
GeneCards (Weizmann)TMED10
Ensembl hg19 (Hinxton)ENSG00000170348 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170348 [Gene_View]  ENSG00000170348 [Sequence]  chr14:75131468-75176646 [Contig_View]  TMED10 [Vega]
ICGC DataPortalENSG00000170348
TCGA cBioPortalTMED10
AceView (NCBI)TMED10
Genatlas (Paris)TMED10
WikiGenes10972
SOURCE (Princeton)TMED10
Genetics Home Reference (NIH)TMED10
Genomic and cartography
GoldenPath hg38 (UCSC)TMED10  -     chr14:75131468-75176646 -  14q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMED10  -     14q24.3   [Description]    (hg19-Feb_2009)
GoldenPathTMED10 - 14q24.3 [CytoView hg19]  TMED10 - 14q24.3 [CytoView hg38]
ImmunoBaseENSG00000170348
Mapping of homologs : NCBITMED10 [Mapview hg19]  TMED10 [Mapview hg38]
OMIM605406   
Gene and transcription
Genbank (Entrez)AJ004913 AK023615 AK056156 AK222972 AK296800
RefSeq transcript (Entrez)NM_006827
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMED10
Cluster EST : UnigeneHs.74137 [ NCBI ]
CGAP (NCI)Hs.74137
Alternative Splicing GalleryENSG00000170348
Gene ExpressionTMED10 [ NCBI-GEO ]   TMED10 [ EBI - ARRAY_EXPRESS ]   TMED10 [ SEEK ]   TMED10 [ MEM ]
Gene Expression Viewer (FireBrowse)TMED10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10972
GTEX Portal (Tissue expression)TMED10
Human Protein AtlasENSG00000170348-TMED10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49755   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49755  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49755
Splice isoforms : SwissVarP49755
PhosPhoSitePlusP49755
Domaine pattern : Prosite (Expaxy)GOLD (PS50866)   
Domains : Interpro (EBI)GOLD_dom    TMP21-related   
Domain families : Pfam (Sanger)EMP24_GP25L (PF01105)   
Domain families : Pfam (NCBI)pfam01105   
Domain families : Smart (EMBL)EMP24_GP25L (SM01190)  
Conserved Domain (NCBI)TMED10
DMDM Disease mutations10972
Blocks (Seattle)TMED10
SuperfamilyP49755
Human Protein Atlas [tissue]ENSG00000170348-TMED10 [tissue]
Peptide AtlasP49755
HPRD12013
IPIIPI00028055   IPI01026466   
Protein Interaction databases
DIP (DOE-UCLA)P49755
IntAct (EBI)P49755
FunCoupENSG00000170348
BioGRIDTMED10
STRING (EMBL)TMED10
ZODIACTMED10
Ontologies - Pathways
QuickGOP49755
Ontology : AmiGOGolgi membrane  kidney development  protein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum-Golgi intermediate compartment  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi apparatus  cis-Golgi network  plasma membrane  intracellular protein transport  intracellular protein transport  ER to Golgi vesicle-mediated transport  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  retrograde vesicle-mediated transport, Golgi to ER  Golgi organization  ER to Golgi transport vesicle membrane  integral component of membrane  syntaxin binding  transport vesicle  COPII-coated ER to Golgi transport vesicle  COPI-coated vesicle  COPI-coated vesicle  trans-Golgi network transport vesicle  secretory granule membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  cargo loading into vesicle  COPI-coated vesicle budding  melanosome  zymogen granule membrane  response to alkaloid  protein-containing complex binding  regulated exocytosis  vesicle targeting, to, from or within Golgi  COPI coating of Golgi vesicle  COPII vesicle coating  protein complex oligomerization  gamma-secretase complex  regulation of amyloid-beta formation  
Ontology : EGO-EBIGolgi membrane  kidney development  protein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum-Golgi intermediate compartment  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  Golgi apparatus  cis-Golgi network  plasma membrane  intracellular protein transport  intracellular protein transport  ER to Golgi vesicle-mediated transport  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  retrograde vesicle-mediated transport, Golgi to ER  Golgi organization  ER to Golgi transport vesicle membrane  integral component of membrane  syntaxin binding  transport vesicle  COPII-coated ER to Golgi transport vesicle  COPI-coated vesicle  COPI-coated vesicle  trans-Golgi network transport vesicle  secretory granule membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  cargo loading into vesicle  COPI-coated vesicle budding  melanosome  zymogen granule membrane  response to alkaloid  protein-containing complex binding  regulated exocytosis  vesicle targeting, to, from or within Golgi  COPI coating of Golgi vesicle  COPII vesicle coating  protein complex oligomerization  gamma-secretase complex  regulation of amyloid-beta formation  
NDEx NetworkTMED10
Atlas of Cancer Signalling NetworkTMED10
Wikipedia pathwaysTMED10
Orthology - Evolution
OrthoDB10972
GeneTree (enSembl)ENSG00000170348
Phylogenetic Trees/Animal Genes : TreeFamTMED10
HOGENOMP49755
Homologs : HomoloGeneTMED10
Homology/Alignments : Family Browser (UCSC)TMED10
Gene fusions - Rearrangements
Fusion : QuiverTMED10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMED10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMED10
dbVarTMED10
ClinVarTMED10
1000_GenomesTMED10 
Exome Variant ServerTMED10
ExAC (Exome Aggregation Consortium)ENSG00000170348
GNOMAD BrowserENSG00000170348
Varsome BrowserTMED10
Genetic variants : HAPMAP10972
Genomic Variants (DGV)TMED10 [DGVbeta]
DECIPHERTMED10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMED10 
Mutations
ICGC Data PortalTMED10 
TCGA Data PortalTMED10 
Broad Tumor PortalTMED10
OASIS PortalTMED10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMED10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMED10
Mutations and Diseases : HGMDTMED10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMED10
DgiDB (Drug Gene Interaction Database)TMED10
DoCM (Curated mutations)TMED10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMED10 (select a term)
intoGenTMED10
Cancer3DTMED10(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605406   
Orphanet
DisGeNETTMED10
MedgenTMED10
Genetic Testing Registry TMED10
NextProtP49755 [Medical]
TSGene10972
GENETestsTMED10
Target ValidationTMED10
Huge Navigator TMED10 [HugePedia]
snp3D : Map Gene to Disease10972
BioCentury BCIQTMED10
ClinGenTMED10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10972
Chemical/Pharm GKB GenePA128394579
Clinical trialTMED10
Miscellaneous
canSAR (ICR)TMED10 (select the gene name)
DataMed IndexTMED10
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMED10
EVEXTMED10
GoPubMedTMED10
iHOPTMED10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:11:59 CET 2019
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