TMED3 (transmembrane p24 trafficking protein 3)

2013-01-01  

Identity

HGNC
TMED3
LOCATION
15q25.1
LOCUSID
23423
ALIAS
C15orf22,P24B,p24g4,p24gamma4,p26
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23423
HGNC: 28889
Ensembl: ENSG00000166557

Variants:

dbSNP: 23423
ClinVar: 23423
TCGA: ENSG00000166557
COSMIC: TMED3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166557ENST00000299705Q9Y3Q3
ENSG00000166557ENST00000299705A0A140VKD1
ENSG00000166557ENST00000424155Q9Y3Q3
ENSG00000166557ENST00000536821F5H4M7
ENSG00000166557ENST00000543455G3V1J9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384112672024TMED3 stabilizes SMAD2 by counteracting NEDD4-mediated ubiquitination to promote ovarian cancer.0
384112672024TMED3 stabilizes SMAD2 by counteracting NEDD4-mediated ubiquitination to promote ovarian cancer.0
353587142023Trafficking protein TMED3 promotes esophageal squamous cell carcinoma.2
359510892023Analysis and Validation of TMED3 correlates with poor prognosis and tumor immune infiltration of glioma.2
353587142023Trafficking protein TMED3 promotes esophageal squamous cell carcinoma.2
359510892023Analysis and Validation of TMED3 correlates with poor prognosis and tumor immune infiltration of glioma.2
337601712021Knockdown of TMED3 inhibits cell viability and migration and increases apoptosis in human chordoma cells.10
344294022021TMED3 promotes the progression and development of lung squamous cell carcinoma by regulating EZR.11
347583702021TMED3 exerts a protumor function in non-small cell lung cancer by enhancing the Wnt/β-catenin pathway via regulation of AKT.7
337601712021Knockdown of TMED3 inhibits cell viability and migration and increases apoptosis in human chordoma cells.10
344294022021TMED3 promotes the progression and development of lung squamous cell carcinoma by regulating EZR.11
347583702021TMED3 exerts a protumor function in non-small cell lung cancer by enhancing the Wnt/β-catenin pathway via regulation of AKT.7
279010212016TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3 signaling.44
279010212016TMED3 promotes hepatocellular carcinoma progression via IL-11/STAT3 signaling.44
249206082014A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12.51

Citation

Dessen P

TMED3 (transmembrane p24 trafficking protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2013-01-01

Online version: http://atlasgeneticsoncology.org/gene/53149/tmed3