Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TMED4 (transmembrane p24 trafficking protein 4)

Identity

Alias (NCBI)ERS25
GMP25iso
HNLF
p24a3
p24alpha3
HGNC (Hugo) TMED4
HGNC Alias symbHNLF
p24alpha3
p24a3
HGNC Previous nametransmembrane emp24 protein transport domain containing 4
LocusID (NCBI) 222068
Atlas_Id 74762
Location 7p13  [Link to chromosome band 7p13]
Location_base_pair Starts at 44577895 and ends at 44582295 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HTT (4p16.3) / TMED4 (7p13)TMED4 (7p13) / DDX56 (7p13)TMED4 (7p13) / ENG (9q34.11)
TMEM241 (18q11.2) / TMED4 (7p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TMED4   22301
Cards
Entrez_Gene (NCBI)TMED4  222068  transmembrane p24 trafficking protein 4
AliasesERS25; GMP25iso; HNLF; p24a3; 
p24alpha3
GeneCards (Weizmann)TMED4
Ensembl hg19 (Hinxton)ENSG00000158604 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158604 [Gene_View]  ENSG00000158604 [Sequence]  chr7:44577895-44582295 [Contig_View]  TMED4 [Vega]
ICGC DataPortalENSG00000158604
TCGA cBioPortalTMED4
AceView (NCBI)TMED4
Genatlas (Paris)TMED4
WikiGenes222068
SOURCE (Princeton)TMED4
Genetics Home Reference (NIH)TMED4
Genomic and cartography
GoldenPath hg38 (UCSC)TMED4  -     chr7:44577895-44582295 -  7p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TMED4  -     7p13   [Description]    (hg19-Feb_2009)
GoldenPathTMED4 - 7p13 [CytoView hg19]  TMED4 - 7p13 [CytoView hg38]
ImmunoBaseENSG00000158604
genome Data Viewer NCBITMED4 [Mapview hg19]  
OMIM612038   
Gene and transcription
Genbank (Entrez)AB097009 AK074557 AK290125 AK294122 AL602839
RefSeq transcript (Entrez)NM_001303058 NM_001303059 NM_001303060 NM_001303061 NM_001303062 NM_182547
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMED4
Alternative Splicing GalleryENSG00000158604
Gene ExpressionTMED4 [ NCBI-GEO ]   TMED4 [ EBI - ARRAY_EXPRESS ]   TMED4 [ SEEK ]   TMED4 [ MEM ]
Gene Expression Viewer (FireBrowse)TMED4 [ Firebrowse - Broad ]
GenevisibleExpression of TMED4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)222068
GTEX Portal (Tissue expression)TMED4
Human Protein AtlasENSG00000158604-TMED4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z7H5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z7H5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z7H5
Splice isoforms : SwissVarQ7Z7H5
PhosPhoSitePlusQ7Z7H5
Domaine pattern : Prosite (Expaxy)GOLD (PS50866)   
Domains : Interpro (EBI)GOLD_dom    TMP21-related   
Domain families : Pfam (Sanger)EMP24_GP25L (PF01105)   
Domain families : Pfam (NCBI)pfam01105   
Domain families : Smart (EMBL)EMP24_GP25L (SM01190)  
Conserved Domain (NCBI)TMED4
DMDM Disease mutations222068
Blocks (Seattle)TMED4
SuperfamilyQ7Z7H5
Human Protein Atlas [tissue]ENSG00000158604-TMED4 [tissue]
Peptide AtlasQ7Z7H5
HPRD13666
IPIIPI00296259   IPI00914891   IPI00914908   IPI00953634   IPI00925777   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z7H5
IntAct (EBI)Q7Z7H5
FunCoupENSG00000158604
BioGRIDTMED4
STRING (EMBL)TMED4
ZODIACTMED4
Ontologies - Pathways
QuickGOQ7Z7H5
Ontology : AmiGOendoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  intracellular protein transport  ER to Golgi vesicle-mediated transport  Golgi organization  integral component of membrane  COPII-coated ER to Golgi transport vesicle  positive regulation of I-kappaB kinase/NF-kappaB signaling  
Ontology : EGO-EBIendoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum-Golgi intermediate compartment  Golgi apparatus  intracellular protein transport  ER to Golgi vesicle-mediated transport  Golgi organization  integral component of membrane  COPII-coated ER to Golgi transport vesicle  positive regulation of I-kappaB kinase/NF-kappaB signaling  
NDEx NetworkTMED4
Atlas of Cancer Signalling NetworkTMED4
Wikipedia pathwaysTMED4
Orthology - Evolution
OrthoDB222068
GeneTree (enSembl)ENSG00000158604
Phylogenetic Trees/Animal Genes : TreeFamTMED4
HOGENOMQ7Z7H5
Homologs : HomoloGeneTMED4
Homology/Alignments : Family Browser (UCSC)TMED4
Gene fusions - Rearrangements
Fusion : QuiverTMED4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMED4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMED4
dbVarTMED4
ClinVarTMED4
1000_GenomesTMED4 
Exome Variant ServerTMED4
GNOMAD BrowserENSG00000158604
Varsome BrowserTMED4
Genetic variants : HAPMAP222068
Genomic Variants (DGV)TMED4 [DGVbeta]
DECIPHERTMED4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTMED4 
Mutations
ICGC Data PortalTMED4 
TCGA Data PortalTMED4 
Broad Tumor PortalTMED4
OASIS PortalTMED4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMED4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTMED4
Mutations and Diseases : HGMDTMED4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMED4
DgiDB (Drug Gene Interaction Database)TMED4
DoCM (Curated mutations)TMED4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMED4 (select a term)
intoGenTMED4
Cancer3DTMED4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612038   
Orphanet
DisGeNETTMED4
MedgenTMED4
Genetic Testing Registry TMED4
NextProtQ7Z7H5 [Medical]
TSGene222068
GENETestsTMED4
Target ValidationTMED4
Huge Navigator TMED4 [HugePedia]
snp3D : Map Gene to Disease222068
BioCentury BCIQTMED4
ClinGenTMED4
Clinical trials, drugs, therapy
Protein Interactions : CTD222068
Pharm GKB GenePA134983854
Clinical trialTMED4
Miscellaneous
canSAR (ICR)TMED4 (select the gene name)
HarmonizomeTMED4
DataMed IndexTMED4
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMED4
EVEXTMED4
GoPubMedTMED4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:32:50 CEST 2020
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