TMED7 (transmembrane p24 trafficking protein 7)

2014-11-01  

Identity

HGNC
LOCATION
5q22.3
LOCUSID
ALIAS
CGI-109,p24g3,p24gamma3,p27

Other Information

Locus ID:

NCBI: 51014
HGNC: 24253
Ensembl: ENSG00000134970

Variants:

dbSNP: 51014
ClinVar: 51014
TCGA: ENSG00000134970
COSMIC: TMED7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134970ENST00000456936Q9Y3B3
ENSG00000134970ENST00000508420G3V2Y2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
224262282012The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation.23
250749782014The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane.13
210480312011Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.5

Citation

Dessen P

TMED7 (transmembrane p24 trafficking protein 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74765/tmed7