TMEFF2 (transmembrane protein with EGF like and two follistatin like domains 2)

2003-02-01  

Identity

HGNC
TMEFF2
LOCATION
2q32.3
LOCUSID
23671
ALIAS
CT120.2,HPP1,TENB2,TPEF,TR,TR-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23671
MIM: 605734
HGNC: 11867
Ensembl: ENSG00000144339

Variants:

dbSNP: 23671
ClinVar: 23671
TCGA: ENSG00000144339
COSMIC: TMEFF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144339ENST00000272771Q9UIK5
ENSG00000144339ENST00000392314Q9UIK5
ENSG00000144339ENST00000409056Q9UIK5

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
158247392005Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk.81
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
209751012010Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
173520302007Detection of aberrant methylation in fecal DNA as a molecular screening tool for colorectal cancer and precancerous lesions.34
124608922002Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma.20
192880102009Methylation of CLDN6, FBN2, RBP1, RBP4, TFPI2, and TMEFF2 in esophageal squamous cell carcinoma.20
215595232011TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma.18
249870552014TMEFF2 deregulation contributes to gastric carcinogenesis and indicates poor survival outcome.18
179424042007Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17.17

Citation

Dessen P

TMEFF2 (transmembrane protein with EGF like and two follistatin like domains 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42587/tmeff2