TMEM129 (transmembrane protein 129, E3 ubiquitin ligase)

2014-11-01  

Identity

HGNC
TMEM129
LOCATION
4p16.3
LOCUSID
92305
ALIAS
D4S2561E

Other Information

Locus ID:

NCBI: 92305
MIM: 615975
HGNC: 25137
Ensembl: ENSG00000168936

Variants:

dbSNP: 92305
ClinVar: 92305
TCGA: ENSG00000168936
COSMIC: TMEM129

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168936ENST00000303277A0AVI4
ENSG00000168936ENST00000382936A0AVI4
ENSG00000168936ENST00000460722H7C4I8
ENSG00000168936ENST00000480360H7C4G7
ENSG00000168936ENST00000536901A0AVI4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
248074182014A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.49
250304482014TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.41
262101832015Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.17
278542842016The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein.2

Citation

Dessen P

TMEM129 (transmembrane protein 129, E3 ubiquitin ligase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74790/tmem129